Research progress on the mechanism of cell senescence associated with idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis(IPF)is an irreversible disease that gradually increases with age,mainly manifested as active dyspnea and progressive progressive worsening,and irreversible.Cell senes-cence is a sign of aging,which is defined as a stable exit from the cell cycle in response to cell damage and stress.In IPF,the mechanisms that lead to cell senescence include telomere dysfunction,DNA damage,cell se-nescence phenotype,mitochondrial dysfunction,inflammatory response and autophagy disorder.With the pro-gress of aging-related research,the relationship between IPF and cell senescence has become more and more intense.This article reviewed the relationship between these factors and the occurrence and development of IPF.
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