Idiopathic pulmonary fibrosis(IPF)is an irreversible disease that gradually increases with age,mainly manifested as active dyspnea and progressive progressive worsening,and irreversible.Cell senes-cence is a sign of aging,which is defined as a stable exit from the cell cycle in response to cell damage and stress.In IPF,the mechanisms that lead to cell senescence include telomere dysfunction,DNA damage,cell se-nescence phenotype,mitochondrial dysfunction,inflammatory response and autophagy disorder.With the pro-gress of aging-related research,the relationship between IPF and cell senescence has become more and more intense.This article reviewed the relationship between these factors and the occurrence and development of IPF.
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