Predictive value of neutrophil-to-lymphocyte ratio and monocyte-to-high-density lipoprotein ratio on the prognosis of acute non-ST-segment elevation myocardial infarction
Objective To investigate the predictive value of neutrophil-to-lymphocyte ratio(NLR)and monocyte-to-high-density lipoprotein ratio(MHR).n the prognosis of acute non-ST-segment elevation myo-cardial infarction(NSTEMI).Methods A retrospective cohort study was conducted to collect clinical data from 144 patients admitted to the emergency department of Wuhan Fourth Hospital from January 2020 to De-cember 2022 and finally diagnosed with NSTEMI.The patients were divided into the MACE group(49 cases)and the non-MACE group(95 cases)according to whether they had the major adverse cardiovascular events(MACE)within six months after discharge.The clinical data of the two groups were compared,and the rela-tionship between NLR,MHR and MACE in the NSTEMI patients was analyzed by multivariate logistic re-gression,and the predictive value of NLR and MHR in predicting the prognosis of NSTEMI patients was ana-lyzed by the receiver operating characteristic(ROC)curve.Results In univariate analysis,compared with the non-MACE group,left ventricular ejection fraction was lower in the MACE group,and the proportion of Killip grade＞Ⅱ,white blood cell count,creatinine,NLR,B-type natriuretic peptide precursor and high-sensitivity troponin were higher at admission,with statistical significance(P＜0.05).The difference in MHR between the two groups was not statistically significant(P=0.916).Multivariate logistic regression showed that NLR was an independent risk factor for MACE in the NSTEMI patients(OR=1.261,95％CI 1.048-1.517,P＜0.05).The ROC curve showed that the area under the curve of NLR was 0.793,the sensitivity was 83.7％,the specifici-ty was 66.3％,and the best cut-off value was 3.12(95％CI 0.72-0.87,P＜0.001).Conclusion NLR is an independent risk factor for the development of MACE in patients with NSTEMI and has good predictive val-ue.This study did not find a correlation between MHR and the development of MACE in patients with NSTE-MI for the time being.
万方数据
维普
