Effect of malnutrition on chemotherapy response and survival in patients with advanced gastric cancer assessed by propensity score matching
Objective To investigate the effect of nutritional status before the first chemotherapy on the tolerance,efficacy,adverse reactions and survival of patients with advanced gastric cancer.Methods A total of 336 patients with advanced gastric cancer admitted to Fujian Cancer Hospital from May 2018 to July 2020 were selected to evaluate the nutritional status before the first chemotherapy by the Global Leadership Initia-tive on Malnutrition(GLIM).The patients were divided into the malnutrition group(116 cases)and the well-nourished group(220 cases)according to nutritional status.The relationship between malnutrition and clinical outcome in the patients with advanced gastric cancer was evaluated by using the propensity score matching method to balance the inter-group confounding factors.Results Among 336 patients with gastric cancer,116(34.5％)had malnutrition.Before matching,there were significant differences in age and tumor size between the two groups(P＞0.05).The 103 pairs were successfully matched by 1∶1 nearest neighbor matching meth-od.After matching,the baseline data between the two groups were balanced.The gastrointestinal reaction,neuropathy and fatigue degree of the malnutrition group were higher than those of the well-nourished group(P＜0.05).The chemotherapy tolerance,curative effect and survival time of the malnutrition group were low-er than those of the well-nourished group(P＜0.05).Conclusion The incidence of malnutrition in the pa-tients with advanced gastric cancer is high,which increases the adverse reaction of chemotherapy and reduces the tolerance and survival time of chemotherapy.
Gastric cancerMalnutritionChemotherapyToleranceSurvival time
万方数据
维普
