Objective To analyze the differences of clinical symptoms and characteristics between aqua-porin 4-immunoglobulin G(AQP4-IgG)positive and AQP4-IgG negative neuromyelitis optica spectrum disor-der(NMOSD).Methods The clinical data of 31 patients with confirmed NMOSD in Zhengzhou Ninth People's Hospital and the First Affiliated Hospital of Henan University of Traditional Chinese Medicine were collect-ed.According to AQP4-IgG results,the patients were divided into AQP4-IgG positive and AQP4-IgG negative groups,including 23 cases in AQP4-IgG positive group and eight cases in AQP4-IgG negative group.Results Most of the patients in the two groups were women,and the difference was not statistically signifi-cant(P＞0.05).There was no significant difference in the inducement before onset between the two groups(P＞0.05).The incidence of autoimmune diseases in AQP4-IgG positive group was higher than that in AQP4-IgG negative group,and the difference between the two groups was statistically significant(P＜0.05).Conclu-sion The majority of NMOSD patients are female,the majority of AQP4-IgG positive patients.AQP4-IgG positive group and negative group are mostly female in terms of gender distribution.The incidence of autoim-mune diseases in AQP4-IgG positive NMOSD patients are higher than those in AQP4-IgG negative NMOSD patients.There is no difference in the presence or absence of incentives before onset and gender distribution between the two groups.
维普
万方数据