原发纵隔CD20阴性弥漫大B细胞淋巴瘤1例并文献复习

Primary mediastinal CD20-negative diffuse large B-cell lymphoma:a case report and literature review

何海涛 ¹王启 ¹赵婕 ¹张海溪 ¹高小丽 ¹姚翔媚¹

扫码查看

作者信息

1. 云南省第一人民医院血液科,云南昆明 650032;昆明理工大学附属医院血液科,云南昆明 650032;云南省血液系统疾病临床医学研究中心,云南昆明 650032
折叠

摘要

回顾性分析1例原发纵隔CD20阴性弥漫大B细胞淋巴瘤病例的临床资料,并复习相关文献.患者,男,26岁反复胸痛3个月,影像学检查提示纵隔巨大占位,于外科行纵隔占位活检,术后免疫组织化学提示:CD20(-)、CD19(+)、PAX-5(+)、CD3(-)、CD5(-)、CD10(-)、TdT(-)、MUM1(+)、CD30(个别+)、Ki-67(约60％+)、BCL-2(+)、C-MYC(10％～20％).诊断为CD20阴性弥漫大B细胞淋巴瘤,予以多疗程联合化疗后,疗效欠佳,病情进展,失访.CD20阴性弥漫大B细胞淋巴瘤侵袭性强,诊治难度大,预后差.

Abstract

The clinical data of one case of primary mediastinal CD20-negative diffuse large B-cell lym-phoma were retrospectively analyzed,and the related literatures were reviewed.One 26-year-old male patient presented with recurrent chest pain for 3 months.Imaging examination showed a large space-occupying lesion in the mediastinum.Postoperative pathological immunohistochemistry showed CD20(-),CD19(+),PAX-5(+),CD3(-),CD5(-),CD10(-),TdT(-),MUM1(+),CD30(individual+),Ki-67(about 60％+),BCL-2(+),C-MYC(10％-20％).After multiple courses of combined chemotherapy,the efficacy was poor,the disease progressed,and he was lost to follow-up.Therefore,CD20-negative diffuse large B-cell lymphoma is highly invasive,difficult to diagnose and treat,and has a poor prognosis.

关键词

弥漫大B细胞淋巴瘤/CD20阴性/纵隔淋巴瘤/文献复习

Key words

Diffuse large B-cell lymphoma/CD20 negative/Mediastinal lymphoma/Literature review

引用本文复制引用

基金项目

云南省血液疾病临床医学中心项目(2021LCZXXF-XY03)

出版年

2024

现代医药卫生

重庆市卫生信息中心

现代医药卫生

影响因子：0.758

ISSN：1009-5519

参考文献量17

段落导航