首页|原发纵隔CD20阴性弥漫大B细胞淋巴瘤1例并文献复习

原发纵隔CD20阴性弥漫大B细胞淋巴瘤1例并文献复习

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回顾性分析1例原发纵隔CD20阴性弥漫大B细胞淋巴瘤病例的临床资料，并复习相关文献。患者，男，26岁反复胸痛3个月，影像学检查提示纵隔巨大占位，于外科行纵隔占位活检，术后免疫组织化学提示:CD20(-)、CD19(+)、PAX-5(+)、CD3(-)、CD5(-)、CD10(-)、TdT(-)、MUM1(+)、CD30(个别+)、Ki-67(约60％+)、BCL-2(+)、C-MYC(10％～20％)。诊断为CD20阴性弥漫大B细胞淋巴瘤，予以多疗程联合化疗后，疗效欠佳，病情进展，失访。CD20阴性弥漫大B细胞淋巴瘤侵袭性强，诊治难度大，预后差。
Primary mediastinal CD20-negative diffuse large B-cell lymphoma:a case report and literature review
The clinical data of one case of primary mediastinal CD20-negative diffuse large B-cell lym-phoma were retrospectively analyzed,and the related literatures were reviewed.One 26-year-old male patient presented with recurrent chest pain for 3 months.Imaging examination showed a large space-occupying lesion in the mediastinum.Postoperative pathological immunohistochemistry showed CD20(-),CD19(+),PAX-5(+),CD3(-),CD5(-),CD10(-),TdT(-),MUM1(+),CD30(individual+),Ki-67(about 60％+),BCL-2(+),C-MYC(10％-20％).After multiple courses of combined chemotherapy,the efficacy was poor,the disease progressed,and he was lost to follow-up.Therefore,CD20-negative diffuse large B-cell lymphoma is highly invasive,difficult to diagnose and treat,and has a poor prognosis.

Diffuse large B-cell lymphomaCD20 negativeMediastinal lymphomaLiterature review

何海涛、王启、赵婕、张海溪、高小丽、姚翔媚

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云南省第一人民医院血液科,云南昆明 650032

昆明理工大学附属医院血液科,云南昆明 650032

云南省血液系统疾病临床医学研究中心,云南昆明 650032

弥漫大B细胞淋巴瘤 CD20阴性 纵隔淋巴瘤 文献复习

云南省血液疾病临床医学中心项目

2021LCZXXF-XY03

2024

10.3969/j.issn.1009-5519.2024.07.017

现代医药卫生
重庆市卫生信息中心

现代医药卫生

影响因子：0.758
ISSN：1009-5519
年,卷(期)：2024.40(7)
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