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血乳酸水平在肝功能衰竭患者疗效中的研究进展

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健康的肝脏是乳酸的主要代谢器官,肝功能衰竭患者体内乳酸水平升高。多项国内外研究证实,血乳酸水平或乳酸清除率在肝功能衰竭患者预后中具有重要价值,构建出包括肝损伤和衰竭评估、AARC评分等含有乳酸指标的新预后模型。乳酸还能提高已有预后模型的效果。此外,乳酸与肝功能衰竭患者并发症存在相关性,同时期望通过提高乳酸清除率为肝功能衰竭患者提供新的治疗 目标,总体上降低肝功能衰竭患者的死亡率。现就血乳酸水平在肝功能衰竭患者治疗疗效中的研究进展进行相关综述。
Research progress of blood lactate level in the treatment of patients with liver failure
Healthy liver is the main metabolic organ of lactate,and the level of lactate in patients with liver failure is increased.A number of domestic and foreign studies have confirmed that blood lactate level or lactate clearance rate has important value in the prognosis of patients with liver failure,and a new prognostic model containing lactate indicators such as liver injury and failure assessment and AARC score has been con-structed.Lactate can also improve the effect of existing prognostic models.In addition,there is a correlation between lactate and complications in patients with liver failure.At the same time,it is also expected to provide new treatment targets for patients with liver failure by increasing lactate clearance rate,and generally reduce the mortality of patients with liver failure.This article reviews the research progress of blood lactate level in the treatment of patients with liver failure.

Liver failureLactate levelPrognosisResearch progress

宋倩、廖盛涛、吕琳、李传飞、梅浙川

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重庆医科大学附属第二医院消化科,重庆 400010

肝功能衰竭 乳酸水平 预后 研究进展 综述

重庆市科卫联合医学科研项目(2024)

2024QNXM053

2024

现代医药卫生
重庆市卫生信息中心

现代医药卫生

影响因子:0.758
ISSN:1009-5519
年,卷(期):2024.40(7)
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