In recent years,although the diagnosis and treatment of cutaneous squamous cell carcinoma have made great progress,the incidence of cutaneous squamous cell carcinoma is increasing year by year.Therefore,there is an urgent need to find new therapeutic methods and targets for the diagnosis and treatment of cutaneous squamous cell carcinoma.As an important means of regulation,post-translational modification of proteins can change the physical and chemical properties,conformation and binding ability of proteins,thus af-fecting their activity,stability and function.At present,the research on protein post-translational modification of cutaneous squamous cell carcinoma focuses on the phosphorylation,ubiquitination,glycosylation and acety-lation of proteins.These modifications can regulate the function of proteins,regulate the corresponding signal transduction pathways,or affect the expression of downstream molecules,thus affecting tumor proliferation,invasion,apoptosis,drug resistance,chemotherapy sensitivity,etc.This article reviews the research progress of post-translational modification of proteins in cutaneous squamous cell carcinoma,which will provide new ideas for precise targeted therapy of cutaneous squamous cell carcinoma.
维普
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