首页|蛋白质翻译后修饰在皮肤鳞状细胞癌中的功能研究进展

蛋白质翻译后修饰在皮肤鳞状细胞癌中的功能研究进展

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近年来，虽然对皮肤鳞状细胞癌的诊断和治疗方法有了很大进步，但其发病率却呈逐年上升趋势。因此，迫切需要为皮肤鳞状细胞癌的诊治寻找新的治疗手段和靶点。蛋白质翻译后修饰作为一种重要的调控手段，可以改变蛋白质的理化性质、构象及与蛋白质的结合能力，进而影响其活性、稳定性及功能。目前，对皮肤鳞癌蛋白质翻译后修饰的研究多集中于蛋白质的磷酸化、泛素化、糖基化及乙酰化修饰，这些修饰可通过调节蛋白的功能，调控相应的信号传导途径，或影响其下游分子的表达，从而影响肿瘤的增殖、侵袭、凋亡、耐药、化疗敏感性等。该文综述皮肤鳞状细胞癌中蛋白质翻译后修饰的研究进展，将为实现皮肤鳞状细胞癌的精准靶向治疗提供新思路。
Research progress on the function of protein post-translational modification in cutaneous squamous cell carcinoma
In recent years,although the diagnosis and treatment of cutaneous squamous cell carcinoma have made great progress,the incidence of cutaneous squamous cell carcinoma is increasing year by year.Therefore,there is an urgent need to find new therapeutic methods and targets for the diagnosis and treatment of cutaneous squamous cell carcinoma.As an important means of regulation,post-translational modification of proteins can change the physical and chemical properties,conformation and binding ability of proteins,thus af-fecting their activity,stability and function.At present,the research on protein post-translational modification of cutaneous squamous cell carcinoma focuses on the phosphorylation,ubiquitination,glycosylation and acety-lation of proteins.These modifications can regulate the function of proteins,regulate the corresponding signal transduction pathways,or affect the expression of downstream molecules,thus affecting tumor proliferation,invasion,apoptosis,drug resistance,chemotherapy sensitivity,etc.This article reviews the research progress of post-translational modification of proteins in cutaneous squamous cell carcinoma,which will provide new ideas for precise targeted therapy of cutaneous squamous cell carcinoma.

Cutaneous squamous cell carcinomaPhosphorylationAcetylationGlycosylationUbiquitinationReview

杨润、乔佳月、王铎蓉、谭千桦、刘欢、王琳

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西安医学院第一临床医学院,陕西西安 710021

西安医学院医学技术学院,陕西西安 710021

西安医学院基础与转化医学研究所/陕西省缺血性心血管疾病重点实验室/陕西省脑疾病重点实验室,陕西西安 710021

皮肤鳞状细胞癌 磷酸化 乙酰化 糖基化 泛素化 综述

陕西省自然科学基础研究计划陕西省大学生创新创业训练计划西安医学院大学生创新创业训练计划西安医学院科研能力提升计划西安医学院博士启动基金陕西省教育厅专项科研项目

2023-JC-QN-0216S2022118400411215220412022NLTS0462021D0C0821JK0885

2024

10.3969/j.issn.1009-5519.2024.07.030

现代医药卫生
重庆市卫生信息中心

现代医药卫生

影响因子：0.758
ISSN：1009-5519
年,卷(期)：2024.40(7)
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