Airway mucus hypersecretion is an important pathophysiological and clinical manifestation of a variety of chronic airway diseases,and is an independent risk factor affecting the prognosis and outcome of the disease.Azithromycin can effectively prevent or reduce the acute exacerbation of chronic airway diseases and inhibit the hypersecretion of airway mucus in chronic airway diseases.However,the specific mechanism is not completely clear,which may be related to the inhibition of the synthesis and secretion of mucin MUC5AC and the inhibition of bacterial biofilm formation.This article summarizes the possible mechanism of azithro-mycin in inhibiting airway mucus hypersecretion and its application in chronic airway diseases,in order to pro-vide reference for the follow-up study and clinical application of azithromycin.
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