Mechanism of aucklandia lappa in the treatment of gastric cancer based on network pharmacology and molecular docking techniques
Objective To explore the mechanism of aucklandia lappa in the treatment of gastric cancer using network pharmacology and molecular docking technology.Methods The pharmacologic database analy-sis platform of traditional Chinese medicine system was used to screen the active components and core targets of aucklandia lappa,and the protein interaction network was constructed to analyze the interaction between proteins of aucklandia lappa in the treatment of gastric cancer.Gene ontology(GO)enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis were used to verify the interaction ac-tivities between active components and key targets,and molecular docking experiments were used to verify the interaction activities.Results After screening,Five active components[Mairin,β-sitosterol,stigasterol,Benzo(a)carbazole,thistrosinin]and five core targets[prostaglandin-endoperoxide synthase(PTGS)2,PTGS1,monoamine oxidase(MAO)A,MAOB,SLC6A3]were determined.A total of 624 GO entries and 85 KEGG signaling pathways were screened through enrichment.Among them,Benzo(a)carbazole had a strong binding capacity with PTGS2,PTGS1,MAOA,and MAOB,and Mairin had a strong binding capacity with SLC6A3.Conclusion Aucklandia lappa mainly interferes with gastric cancer through multiple components,which may play a key role by interfering with core target proteins.
万方数据
维普
