Body fat distribution and its correlation with insulin resistance in patients with type 2 diabetes
Objective To investigate the relationship between body fat distribution and insulin resist-ance(IR)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 2 790 T2DM patients hospi-talized in the department of endocrinology of the hospital from January 2019 to December 2020 were selected and divided into the IR group(1 915 cases)and the non-IR group(875 cases)according to the presence or ab-sence of IR.IR status was assessed by TyG index,and the correlation between visceral adipose tissue(VAT),subcutaneous adipose tissue(SAT)area and other clinical indicators(body mass index(BMI),glycosylated he-moglobin(HbA1c),triglyceride(TG),low density lipoprotein(LDL)and high density lipoprotein(HDL),etc.),and the influence of body fat distribution area on IR were analyzed.Results BMI,waist circumference,hip circumference,waist-to-hip ratio,diastolic blood pressure,TG,TyG index,uric acid,creatinine level and VAT area in male patients were higher than those in female patients,while age,waist-to-height ratio,systolic blood pressure,cholesterol,HDL,LDL level and SAT area were lower than those in female patients,with sta-tistical significance(P＜0.05).VAT area were positively correlated with BMI,systolic blood pressure,dias-tolic blood pressure,waist circumference,waist-to-hip ratio,TG,TyG index,and uric acid level(r＞0,P＜0.05),and negatively correlated with HbA1c and HDL level(r＜0,P＜0.05).SAT area was positively corre-lated with BMI,waist circumference,waist-to-hip ratio,cholesterol,LDL,TyG index,and uric acid level(r＞0,P＜0.05),and negatively correlated with HDL level(r＜0,P＜0.05).Diastolic blood pressure,waist-to-hip ratio,HbA1c,uric acid level,VAT and SAT area in the IR group were higher than those in the non-IR group,while age,systolic blood pressure and HDL level were lower than those in the non-IR group,with statistical sig-nificance(P＜O.05).VAT area,diastolic blood pressure and HbA1c were independent risk factors for IR(OR＞1,P＜0.05),while HDL was protective factor(OR＜1,P＜0.05).Conclusion There is gender difference in body fat distribution in T2DM patients,and VAT is a risk factor for IR.
Type 2 diabetesBody fat distributionInsulin resistanceTriglyceride glucose index
万方数据
维普
