Effect of traditional Chinese medicine for supplementing qi and activating blood circulation on the cardiac function in patients with chemotherapy
Objective To explore early monitoring indicators of cancer therapy-related cardiovascular toxicity(CTR-CVT)and the preventive effect of traditional Chinese medicine for supplementing qi and activa-ting blood circulation on CTR-CVT.Methods A total of 40 malignant tumor patients who underwent anti-tumor treatment and were diagnosed by pathological examination in the hospital from January 2019 to January 2022 were randomly divided into the control group and the treatment group according to the ratio of 1∶1.The control group received chemotherapy,while the treatment group combined traditional Chinese medicine for supplementing qi and activating blood circulationo on the basis of chemotherapy.The levels of myocardial en-zyme spectrum[α-hydroxybutyrate dehydrogenase(α-HBDH),lactate dehydrogenase(LDH),creatine kinase(CK),creatine kinase isoenzyme(CK-MB),aspartate aminotransferase(AST)],B-type natriuretic peptide(BNP),cardiac troponin Ⅰ(CTN Ⅰ),and left ventricular ejection fraction(LVEF)between two groups were compared,and the occurrence of electrocardiogram abnormalities and cardiovascular adverse events were ana-lyzed.Results The levels of CK,CK-MB,α-HBDH,LDH,BNP after chemotherapy in the control group were higher than before chemotherapy,while the levels of AST,CTN Ⅰ were lower than before chemotherapy,with no statistical significance(P＞0.05).There was no statistically significant difference in α-HBDH,LDH,BNP,AST,CK,CK-MB and CTN Ⅰ levels between after chemotherapy and before chemotherapy in the treat-ment group(P＞0.05).There were statistically significant differences in BNP,α-HBDH and LDH levels be-tween the two groups after chemotherapy(P＜0.05),but there were no statistically significant differences in the levels of AST,CK-MB,CK,CTN Ⅰ(P＞0.05).There were statistically significant difference in the LVEF levels and incidence of cardiovascular adverse events after chemotherapy between the two groups(P＜0.05).There were no statistically significant difference in the myocardial enzyme spectrum indicators,BNP,CTN Ⅰlevel,and electrocardiogram abnormalities after chemotherapy between the two groups(P＞0.05).Conclusion Myo-cardial enzyme spectrum,BNP and CTN Ⅰ can be used as early monitoring indicators for CTR-CVT.Tradi-tional Chinese medicine for supplementing qi and activating blood circulation has a certain degree of preventive effect on CTR-CVT.It can improve the heart function and BNP,LVEF levels of patients,and reduce the inci-dence of cardiovascular adverse events.
Cardiovascular toxicityTraditional Chinese medicineTumorCardiovascular ad-verse events
万方数据
维普
