Study on the predictive value of APACHE Ⅱ score combined with serum PCT and hs-CRP in severe pneumonia with respiratory failure
Objective To explore the predictive value of the acute physiology and chronic health evalua-tion Ⅱ(APACHE Ⅱ)combined with serum procalcitonin(PCT)and hypersensitive C-reactive protein(hs-CRP)in severe pneumonia complicated with respiratory failure.Methods A total of 120 patients with severe pneumonia who were treated in the hospital from February 2020 to February 2023 were selected and divided into the control group(85 cases)and the observation group(35 cases)according to the combined respiratory failure.The APACHE Ⅱ score,serum PCT and hs-CRP levels between two groups were compared,and the in-fluencing factors of severe pneumonia combined with respiratory failure and the predictive efficacy of related indicators were analyzed.Results There were statistically significant differences in terms of smoking history,chronic obstructive pulmonary disease(COPD)and oxygenation index between the two groups(P＜0.05).The APACHE Ⅱ score,serum PCT and hs-CRP levels of the observation group were higher than those of the con-trol group,and the differences were statistically significant(P＜0.05).Smoking,concomitant COPD,APACHEⅡ score,PCT,hs-CRP were risk factors for severe pneumonia with respiratory failure(P＜0.05),while oxygenation index was a protective factor(P＜0.05).The predictive sensitivity and area under the re-ceiver operating characteristic curve of APACHE Ⅱ score,serum PCT and hs-CRP were higher than those when each indicator was used alone(P＜0.05).However,there was no statistically significant difference in specificity between the two groups(P＞0.05).Conclusion The APACHE Ⅱ score combined with serum PCT and hs-CRP has a high predictive efficiency for severe pneumonia complicated with respiratory failure.
Severe pneumoniaRespiratory failureProcalcitoninHypersensitivity C-reactive protein
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