Alzheimer's disease(AD)is a neurodegenerative disease with a hidden onset and complex pa-thology.The clinical diagnosis of AD has probably developed to the middle or late stage.The relative protein biomarkers in the cerebrospinal fluid can pass through the blood-brain barrier and participate the peripheral circulation in the very early stage of AD.Peripheral blood biomarker detection has the characteristics of con-venient collection and minimal trauma,and is expected to become the most promising early screening and fol-low-up method.However,the traditional immunoassay methods cannot meet the demand for the accurate quantitative analysis of ultra-trace protein biomarkers in peripheral blood.In recent years,the newly developed immunoassay techniques in recent years have been widely applied in the analysis of ultra trace protein biomar-kers.The paper reviews the recent research progress and analysis methods of early peripheral blood biomark-ers of AD.
维普
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