The neurotoxicity caused by obesity leads to changes in brain structure and network,resul-ting in cognitive decline in obese individuals and hindering the recovery of bodily functions.Therefore,obesity may be a complex disease related to the body and brain.Related studies have found that changes in the brain network of obese individuals may be the main cause of cognitive impairment associated with obesity.The arti-cle briefly elaborates on the mediating and regulatory factors between obesity and changes in brain networks,and explores the abnormal mechanisms of brain functional networks in obese individuals,providing new strat-egies for screening,preventing,treating,and monitoring obesity combined with cognitive impairment.
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