Effect of compound TongYe burn oil combined with recombinant human basic fibroblast growth factor gel in the treatment of pharyngeal leakage after laryngeal cancer operation
Objective To study the efficacy of compound TongYe burn oil combined with recombinant human basic fibroblast growth factor gel(rh-bFGF)in the treatment of patients with pharyngeal leakage after laryngeal cancer surgery.Methods A total of 60 patients with pharyngeal fistula after laryngeal cancer resec-tion admitted to our hospital from January 2018 to December 2022 were selected and divided into treatment group and control group by random number table method,with 30 cases in each group.The treatment group was treated with compound TongYe burn oil combined with rh-bFGF gauze for local dressing change,while the control group was only treated with rh-bFGF gauze for local dressing change.The efficacy,cure time and cost of pharyngeal leakage were evaluated.Results There was no significant difference in the effective rate[46.67％(14/30)]and total effective rate[96.67％(29/30)]between the treatment group and the control group[30.00％(9/30)and 86.67％(26/30)](P＞0.05).After treatment,the serum interleukin-6 level[(16.56±4.26)pg/L]in the treatment group was lower than that before treatment[(53.96±6.28)pg/L]and that in the control group[(24.35±3.61)pg/L],the postoperative hospitalization cost[(57 817.7±2 203.7)yuan]was significantly less than that in the control group[(61 915.5±1 972.9)yuan],and the hospitaliza-tion time[(19.27±2.35)d]was significantly shorter than that in the control group[(24.77±2.16)d],the differences were statistically significant(P＜0.05).Conclusion The effect of compound Tongye burn oil com-bined with rh-bFGF in the treatment of postoperative pharyngeal leakage of laryngeal cancer is equivalent to that of routine use of rh-bFGF.It can promote healing and reduce inflammatory reaction.Compared with rou-tine use of rh-bFGF,it can shorten hospitalization time and cost,and has good clinical benefits.It is worthy of popularization and application.
Compound TongYe burn oilRecombinant human basic fibroblast growth factor gelPharyngeal leakage after laryngeal cancer operation
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