Monitoring effect of cholinesterase,procalcitonin and D-dimer on pulmonary infection in patients with acute organophosphorus poisoning
Objective To investigate the role of cholinesterase(ChE),procalcitonin(PCT)and D-dimer(D-D)in monitoring pulmonary infection in patients with acute organophosphorus poisoning(AOPP).Methods 104 cases of AOPP patients admitted to our hospital from March 2021 to June 2022 were selected as the study objects,and were divided into the infected group(39 cases)and the uninfected group(65 cases)according to whether they had pulmonary infection.The general clinical data of the two groups were compared,and the correlation be-tween ChE,PCT,D-D levels and other clinical differential indicators and pulmonary infection was analyzed.The risk factors and protective factors of pulmonary infection in AOPP patients were analyzed by logistic re-gression model.The receiver operating characteristic curve was drawn to analyze the diagnostic value of com-bined detection of each index in AOPP patients complicated with pulmonary infection.Results Organophos-phorus intake,white blood cell count(WBC),acute physiology and chronic health status evaluation Ⅱ(A-PACHE Ⅱ)scores,PCT and D-D levels in the infected group were significantly higher than those in the non-infected group,and ChE activity was significantly lower than that in the non-infected group,with statistical significance(P＜0.05).ChE activity was negatively correlated with organophosphorus intake,WBC,APACHEⅡ score and pulmonary infection,while PCT and D-D levels were positively correlated,with statistical signifi-cance(P＜0.05).Organophosphorus intake,WBC,APACHE Ⅱ scores,and PCT and D-D levels were all risk factors for pulmonary infection in AOPP patients,and ChE activity was the protective factor,with statistical significance(P＜0.05).The area under the curve of AOPP patients complicated with pulmonary infection de-tected by the combination of ChE,PCT and D-D was 0.803.Conclusion In patients with AOPP complicated with pulmonary infection,the expression of ChE in serum is down-regulated,while the expression of PCT and D-D is up-regulated.The combined detection in patients with AOPP complicated with pulmonary infection has diagnostic value,and can be used as an effective indicator for the diagnosis of pulmonary infection in patients with AOPP.
万方数据
维普
