Effect of budesonide formoterol inhaler combined with theophylline extended-release tablets on airway inflammation and sleep quality in patients with COPD
Objective To investigate the effect of budesonide formoterol inhaler combined with theo-phylline extended-release tablets on airway inflammation and sleep quality in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 130 patients with COPD admitted to our hospital from Janu-ary 2021 to January 2023 were selected and divided into the observation group and the control group by ran-dom number table method,with 65 cases in each group.The control group was treated with budesonide for-moterol inhalation,and the observation group was treated with theophylline extended-release tablets on the basis of budesonide formoterol inhaler treatment.The airway inflammation indexes[including tumor necrosis factor-α,interleukin-4(IL-4),IL-6,IL-8,etc.],lung function indexes(including 1-second exertional expiratory volume,exertional lung capacity,maximal expiratory flow rate,etc.),sleep quality(Pittsburgh Sleep Quality Index Score),and the occurrence of complications were compared between the two groups of patients before and after the treatment.Results The levels of tumor necrosis factor-α,IL-4,IL-6 and IL-8 in the induced spu-tum of the patients in the observation group after treatment,as well as the Pittsburgh Sleep Quality Index score were significantly lower than those before treatment and in the control group,and the levels of exertional expiratory volume in one second,exertional lung capacity and maximal expiratory flow rate were significantly higher than those of the pre-treatment and control groups,and the number of nocturnal respiratory distress during the period of treatment was significantly less than that of the control group,and the difference was sta-tistically significant(P＜0.05).And there was no statistically significant difference in the incidence of compli-cations between the groups(P＞0.05).Conclusion Budesonide formoterol inhaler combined with theophyl-line extended-release tablets can effectively inhibit airway inflammation and improve lung function and sleep quality in patients with COPD.At the same time,it has a high safety profile.
万方数据
维普
