摘要
目的 系统评价中国0～5岁儿童发生缺铁性贫血(IDA)的影响因素.方法 系统检索中国知网、维普资讯中文期刊服务平台、万方医学网、SinoMed、The Cochrane Library、Embase,PubMed、Web of Science等数据库中公开发表的相关研究,检索时间为建库至2023年3月.由2名研究员独立进行文献筛选、纳入研究中相关资料的提取及偏倚风险的评估后采用RevMan5.4软件进行meta分析,效应量为各影响因素的优势比(OR)及其95％可信区间(95％CI).结果 共纳入文献20篇包括55 388例儿童,其中IDA 17 741例.6～12月龄、男童、早产、母亲文化程度低、母亲孕期贫血、特别是孕晚期贫血、家庭收入低是发生IDA的危险因素(OR=2.74、1.53、4.67、2.16、3.05、4.64、1.24,95％CI 1.80～4.17、1.28～1.83、1.96～11.15、1.30～3.57、2.54～3.66、3.53～6.10、1.16～1.33),4～6月龄添加辅食、添加富含铁的辅食是发生IDA的保护性因素(OR=0.19、0.56,95％CI 0.10～0.39、0.41～0.75).结论 6～12月龄、男童、早产、母亲文化程度低、母亲孕期贫血(特别是孕晚期贫血)、家庭收入低可增加中国0～5岁儿童发生IDA的风险,而4～6月龄添加辅食、给儿童添加富含铁的辅食会降低其发生IDA的风险.
Abstract
Objective To systematically evaluate the Influencing factors of iron deficiency anemia(IDA)in 0-5 years old children in China.Methods The relevant studies published in China National Knowledge Infrastructure(CNKI),VIP,Wanfang Data,SinoMed,The Cochrane Library,Embase,PubMed,and Web of Science databases and other databases were systematically searched.The search time limit was from the establishment of the database to March 2023.Two researchers independently screened the literature,extracted the relevant data from the included stud-ies,and assessed the risk of bias.RevMan 5.4 software was used for Meta-analysis.Results A total of 20 studies in-volving 55 388 children were included,including 17 741 cases of IDA.The results of meta-analysis showed that 6 to 12 months old(OR=2.74,95％CI 1.80-4.17),male children(OR=1.53,95％CI 1.28-1.83),prematurity(OR=4.67,95％CI 1.96-11.15),low maternal education(OR=2.16,95％CI 1.30-3.57),maternal anemia during preg-nancy(OR=3.05,95％CI 2.54-3.66),especially maternal anemia in the third trimester(OR=4.64,95％CI 3.53-6.10),and low household income(OR=1.24,95％CI 1.16-1.33)were risk factors for IDA,and 4 to 6 months of age to add complementary food(OR=0.19,95％CI 0.10-0.39),adding iron-rich complementary foods(OR=0.56,95％CI 0.41-0.75)were protective factor for IDA in 0-5 years old children.Conclusion 6 to 12 months old,male children,prematurity,low maternal education,anemia during pregnancy(especially in the third trimester),and low household income may increase the risk of IDA in 0-5 years old children in China.4 to 6 months of age to add com-plementary food and adding iron-rich complementary foods can reduce the risk of IDA.
基金项目
四川省科技厅重点研发项目(23ZDYF2075)
成都市科技局科技创新研发项目(2022-YF05-01621-SN)
电子科技大学附属医院·四川省人民医院科研项目(2021ZX08)
万方数据