Meta-analysis of influencing factors of iron deficiency anemia in 0-5 years old children in China
Objective To systematically evaluate the Influencing factors of iron deficiency anemia(IDA)in 0-5 years old children in China.Methods The relevant studies published in China National Knowledge Infrastructure(CNKI),VIP,Wanfang Data,SinoMed,The Cochrane Library,Embase,PubMed,and Web of Science databases and other databases were systematically searched.The search time limit was from the establishment of the database to March 2023.Two researchers independently screened the literature,extracted the relevant data from the included stud-ies,and assessed the risk of bias.RevMan 5.4 software was used for Meta-analysis.Results A total of 20 studies in-volving 55 388 children were included,including 17 741 cases of IDA.The results of meta-analysis showed that 6 to 12 months old(OR=2.74,95％CI 1.80-4.17),male children(OR=1.53,95％CI 1.28-1.83),prematurity(OR=4.67,95％CI 1.96-11.15),low maternal education(OR=2.16,95％CI 1.30-3.57),maternal anemia during preg-nancy(OR=3.05,95％CI 2.54-3.66),especially maternal anemia in the third trimester(OR=4.64,95％CI 3.53-6.10),and low household income(OR=1.24,95％CI 1.16-1.33)were risk factors for IDA,and 4 to 6 months of age to add complementary food(OR=0.19,95％CI 0.10-0.39),adding iron-rich complementary foods(OR=0.56,95％CI 0.41-0.75)were protective factor for IDA in 0-5 years old children.Conclusion 6 to 12 months old,male children,prematurity,low maternal education,anemia during pregnancy(especially in the third trimester),and low household income may increase the risk of IDA in 0-5 years old children in China.4 to 6 months of age to add com-plementary food and adding iron-rich complementary foods can reduce the risk of IDA.
Iron deficiency anemiaPreschoolerInfluencing factorsMeta-analysisChina
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