Expression and prognostic significance of HAUS5 in renal clear cell carcinoma
Objective To investigate the expression of Augmin like complex subunit 5(HAUS5)gene and its prognostic significance in renal clear cell carcinoma(RCCC),elucidating its potential mechanisms in the occurrence and development of RCCC through bioinformatics methods and various analytical approaches.Methods Pan-cancer analysis was conducted using the TIMER2 website.Human protein atlas database was utilized to obtain immunohistochemistry-based antibody-specific staining scores for RCCC.Additionally,gene mRNA expression levels and related clinical data for RCCC were downloaded from the Cancer Genome Atlas database.mRNA expression levels and associated clinical data of HAUS5 gene in RCCC were organized using R and Excel software.Patients were categorized into the high and the low expression groups based on the me-dian HAUS5 expression level.SPSS27.0 and R software were used for survival analysis,functional analysis,and visualization.Results HAUS5 exhibited high expression in both RCCC tissues and cells.Higher expres-sion of HAUS5 in RCCC was associated with an increased risk of mortality,with statistically significant differ-ences(hazard ratio=1.744,95%confidence interval:1.286-2.365,P<0.001).Other clinical variables sig-nificantly associated with overall survival[such as distant metastasis(M stage),clinical stage,and primary tumor status(T stage)]also had an impact(hazard ratio=1.550,1.866,1.891,95%confidence interval:1.302-1.846,1.637-2.126,1.608-2.225,P<0.001).Conclusion HAUS5 is highly expressed in both RCCC tissues and cells and is closely associated with the progression and adverse prognosis of RCCC,sugges-ting it as a potential target for clinical treatment of RCCC.
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