Effect of Lianzhu Xiaoke Prescription on glucose and lipid metabolism and micro-inflammatory state in patients with newly diagnosed type 2 diabetes mellitus with dampness-heat binding and blood stasis syndrome
Objective To investigate the effect of Lianzhu Xiaoke Prescription on glucose and lipid me-tabolism and micro-inflammation state in patients with newly diagnosed type 2 diabetes mellitus(T2DM)of dampness-heat binding and blood stasis syndrome.Methods A total of 80 patients with newly diagnosed T2DM who were admitted to the outpatient or inpatient department of endocrinology in the hospital from March 2020 to February 2022 were randomly divided into observation group and control group Using the ran-dom number table method,with 40 cases in each group.The control group was treated with metformin orally,and the observation group was treated with Lianzhu Xiaoke Prescription.The course of treatment was eight weeks.The clinical efficacy,TCM syndrome scores,glucose and lipid metabolism indexes(fasting blood glu-cose,two hours postprandial blood glucose,homeostasis model insulin resistance index,triglyceride,low densi-ty lipoprotein cholesterol,etc.),micro-inflammatory indexes(interleukin-6,C-reactive protein,tumor necrosis factor-α,homocysteine,etc.)were compared between the two groups,and the occurrence of adverse events during the course of treatment was recorded.During the study,four patients in the observation group fell off and 36 patients were finally included.In the control group,three cases were lost and 37 cases were finally ad-mitted.Results The total effective rate of the observation group was significantly higher than that of the con-trol group[94.44%(34/36)vs.78.38%(29/37)],and the TCM syndrome score was significantly lower than that of the control group after the treatment,and the differences were statistically significant(P<0.05).Compared with before treatment,the levels of fasting blood glucose,two hours postprandial blood glucose,tri-glyceride,low density lipoprotein cholesterol,homeostasis model insulin resistance index,interleukin-6,C-reac-tive protein,tumor necrosis factor-α and homocysteine in the two groups were significantly decreased after treatment,and the decrease of each index in the observation group was significantly better than that in the control group,the differences were statistically significant(P<0.05).No adverse events occurred in the two groups during the study.Conclusion Lianzhu Xiaoke Prescription can improve the clinical symptoms of pa-tients with newly diagnosed T2DM,inhibit the release of inflammatory cytokines,restore the function of glu-cose and lipid metabolism,and improve the clinical efficacy.
Lianzhu Xiaoke PrescriptionNewly diagnosed type 2 diabetes mellitusDampness-heat binding and blood stasis syndromeGlucose and lipid metabolismMicro-inflammatory stateTreatment outcome
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