Relationship between serum CRP,PCT,CaN and ventricular remodeling in patients with acute myocardial infarction and its impact on prognosis
Objective To investigate the relationship between serum C-reactive protein(CRP),procal-citonin(PCT),calcineurin(CaN)and ventricular remodeling in patients with acute myocardial infarction(AMI)and its impact on prognosis.Methods A total of 126 patients with AMI admitted to Puyang County People's Hospital from January 2020 to August 2022 were divided into ventricular remodeling group(54 ca-ses)and non-ventricular remodeling group(72 cases).According to the prognosis at 12 months after treat-ment,they were divided into poor prognosis group(25 cases)and good prognosis group(101 cases).In addi-tion,63 healthy subjects were selected as the normal control group.The levels of serum CRP,PCT and CaN at admission were compared among the three groups.The relationship between serum CRP,PCT,CaN and ven-tricular remodeling[left ventricular end-systolic volume(LVESV),end-systolic dispersion(DISPES),left ventricular end-diastolic volume(LVEDV),end-diastolic dispersion(DISPED),left ventricular ejection frac-tion(LVEF),etc.]was analyzed.The levels of serum CRP,PCT and CaN in patients with different prognosis were compared.The predictive value of serum CRP,PCT and CaN on prognosis and its impact on prognosis were analyzed.Results The levels of serum CRP,PCT,CaN,LVEDV,LVESV,DISPES and DISPED in the ventricular remodeling group were significantly higher than those in the non-ventricular remodeling group and the normal control group,and the LVEF in the ventricular remodeling group was significantly lower than that in the non-ventricular remodeling group and the normal control group.The levels of serum CRP,PCT and CaN in the poor prognosis group were significantly higher than those in the good prognosis group.Serum CRP,PCT and CaN were negatively correlated with LVEF,and positively correlated with LVEDV,LVESV,DISPES and DISPED,with statistically significant differences(P<0.05).The area under the receiver operat-ing characteristic curve of serum CRP,PCT and CaN combined to predict the poor prognosis of AMI patients was 0.912,which was better than that of each serum index alone,and the difference was statistically signifi-cant(P<0.05).The risk of poor prognosis in AMI patients with high levels of serum CRP,PCT and CaN was 2.522,3.024 and 3.958 times higher than that in patients with low levels.Conclusion The high expression of serum CRP,PCT and CaN is not only related to ventricular remodeling in AMI patients,but also affects their prog-nosis.Combined detection can be used as an important auxiliary index to predict poor prognosis.
Acute diseaseMyocardial infarctionC-reactive proteinCalcitoninVentricular remodelingPrognosisAnalysis of influencing factors
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