高迁移率族蛋白B1在临床相关疾病中的作用研究进展
Research progress on the role of high mobility group box-1 protein in clinically relevant diseases
曾雨竹 1吴一凡 1孟林红 1伍行 1丁文文 2屈小芹2
作者信息
- 1. 荆楚理工学院 医学部,湖北 荆门 448000
- 2. 荆楚理工学院 基础医学教研室,湖北 荆门 448000
- 折叠
摘要
高迁移率族蛋白B1(HMGB1)是由巨噬细胞释放的一种具有晚期促炎作用的核蛋白.近年来,HMGB1作为一种新型炎症因子,国内外学者均对其进行了广泛研究,发现其在许多疾病中均充当炎症介质,发挥细胞因子活性,从而参与机体损伤.该文主要对HMGB1在心血管系统、肾脏、肝脏及胰腺等相关疾病中的损伤作用,以及其可能的机制进行了综述,以便为临床诊断和研究相关疾病提供依据.
Abstract
High mobility group box-1 protein(HMGB1)is a nuclear protein released by macrophages with late proinflammatory effect.In recent years,as a new type of inflammatory factor,HMGB1 has been widely studied by scholars at home and abroad.It has been found that this protein can act as an inflammatory mediator in many diseases,and then play a cytokine activity and participate in body damage.This article dis-cussed the damage of HMGB1 in cardiovascular system,kidney,liver,pancreas and other related diseases and its possible mechanism,in order to provide a basis for clinical diagnosis and research of relevant diseases.
关键词
高迁移率族蛋白B1/高血压/病毒性肝炎/急性胰腺炎/综述Key words
High mobility group box-1 protein/Hypertension/Viral hepatitis/Acute pancreatitis/Review引用本文复制引用
基金项目
湖北省大学生创新创业训练计划(S202211336039)
湖北省教育厅科研项目(D20224301)
荆楚理工学院校级科学研究项目(ZD202001)
出版年
2024
国家科技期刊平台
NSTL
万方数据