Research progress on the role of high mobility group box-1 protein in clinically relevant diseases
High mobility group box-1 protein(HMGB1)is a nuclear protein released by macrophages with late proinflammatory effect.In recent years,as a new type of inflammatory factor,HMGB1 has been widely studied by scholars at home and abroad.It has been found that this protein can act as an inflammatory mediator in many diseases,and then play a cytokine activity and participate in body damage.This article dis-cussed the damage of HMGB1 in cardiovascular system,kidney,liver,pancreas and other related diseases and its possible mechanism,in order to provide a basis for clinical diagnosis and research of relevant diseases.
High mobility group box-1 proteinHypertensionViral hepatitisAcute pancreatitisReview
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