Study on Duffy blood group antibody distribution and blood transfusion strategy
Objective To analyze the distribution characteristics of unexpected antibodies in Duffy blood group system and to explore the blood transfusion strategy of patients.Methods The screening and i-dentification data of accidental antibodies in patients from January 2012 to December 2022 in the General Hos-pital of Western Theater Command PLA were collected.The Duffy phenotype of red blood cells in patients with Duffy blood group was detected.The causes of antibodies were analyzed by disease history,pregnancy history and blood transfusion history,and the blood transfusion strategy was discussed.Results Accidental antibodies were detected in 2 128(0.6％)of 351 957 patients,and in 34 cases(0.009 7％)of Duffy blood group accidental antibodies,including 26 cases(76.5％)of anti-Fyb,three cases(8.8％)of anti-Fya,three ca-ses(8.8％)of anti-Fyb+anti-E,1 case(2.9％)of anti-Fyb+anti-Lea,one case(2.9％)of anti-Fyb+anti-E+anti-c,33 cases(97.1％)of immunoglobulin G(IgG)antibody,and one case(2.9％)of IgG+IgM antibody.It is mainly produced by immune stimulation of pregnancy or blood transfusion.Among the 34 patients with unexpected antibody of Duffy blood group,two patients were infused with autologous blood(4 U),six pa-tients were infused with allogeneic blood,and the same ABO and Rh blood groups were transfused.The corre-sponding antigen-negative suspended red blood cells of Duffy antibody were 36.5 U,and there were no adverse reactions of blood transfusion.33 patients were improved and discharged,and one patient gave up treatment due to multiple organ failure.Conclusion Unexpected antibodies of Duffy blood group system are rare,which can lead to hemolytic transfusion reaction and hemolytic disease of the newborn,mainly due to pregnancy or immune stimulation of blood transfusion.The detection rate of anti-Fya is much lower than that of anti-Fyb.Various methods should be used to ensure the safety of clinical blood transfusion.
万方数据
维普
