Analysis of Influencing factors of severe pneumonia in HIV/AIDS patients
Objective To investigate the factors influencing the development of severe pneumonia in pa-tients with human immunodeficiency virus(HIV)/acquired immunodeficiency syndrome(AIDS).Methods This study retrospectively analyzed the clinical data of 139 patients with HIV/AIDS combined with pulmonary infections admitted to the Department of Infectious Diseases of General Hospital of Ningxia Medi-cal University from January 2017 to August 2023,among which 48 cases were in the severe pneumonia group and 91 cases were in the non-severe pneumonia group.The influencing factors on the occurrence of severe pneumonia in patients with HIV/AIDS were analyzed by using logistic regression,and the predictive value of the indicators for severe pneumonia was analyzed by plotting the work characteristics of the subjects(ROC)curves.Results The incidence of severe pneumonia was 34.5％(48/139)in 139 patients with HIV/AIDS co-infection of the lungs.Univariate analysis showed that cough,shortness of breath,percentage of neutrophils,percentage of lymphocytes,absolute value of lymphocytes,prothrombin activity(PTA),CD4+T and CD8+T lymphocyte counts,neutrophil/lymphocyte ratio(NLR),albumin,number of pathogens greater than or equal to two,and continuous strong antiretroviral therapy(ART)treatment(＞three months)were significantly associated with severe pneumonia in HIV/AIDS patients(P＜0.05).Logistic stepwise regression analysis showed that previous pneumocystis pneumonia(PCP),number of pathogens greater than or equal to two,ele-vated NLR,elevated PTA,and shortness of breath were independent risk factors for severe pneumonia in HIV/AIDS patients,continuous ART treatment(＞three months)and CD8+T cell count were independent protective factors(P＜0.05).The area under the curve of multi-factor combined prediction is the largest(AUC=0.917,95％CI 0.873-0.961,P＜0.01).Conclusion The occurrence of severe pneumonia in HIV/AIDS patients is closely related to previous PCP,number of pathogens greater than or equal to two,high NLR,high PTA,shortness of breath,continuous ART treatment(＞three months),CD8+T cell count.Multi-factor combined prediction have good predictive value.
Human immunodeficiency virusAcquired immunodeficiency syndromeSevere pneu-moniaPulmonary infectionRisk factorsPredictive value
万方数据
维普
