A clinical control study on the treatment of coronary microvascular stenosis with drug coated balloon
Objective To analyze the efficacy of drug coated balloon(DCB)in the treatment of coro-nary microvascular stenosis and the risk factors for restenosis.Methods A retrospective analysis was conduc-ted on 160 patients with coronary microvascular stenosis who underwent percutaneous transluminal coronary angioplasty(PTCA)with DCB intervention in this hospital from December 2021 to June 2023.Among them,90 patients were followed up for 6 to 12 months after the procedure.Basic clinical data,lipid profiles[total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),homocysteine(Hcy),high-sensitivity C-reactive protein(hs-CRP)],and procedural de-tails were compared between 44 patients with restenosis after treatment(the study group)and 46 patients without restenosis after treatment(the control group).Results There were no significant differences in terms of gender,age,smoking history,obesity,history of previous percutaneous coronary intervention(PCI),hyper-tension,diabetes,chronic renal failure,hyperthyroidism,and hypothyroidism between the two groups(P＞0.05).There were also no significant differences in TC,TG,HDL-C,LDL C,Hcy,and hs-CRP levels between the two groups(P＞0.05).However,there was significant difference in DCB diameter between the two groups(P＜0.05),while there were no significant differences in DCB length,release pressure,release dura-tion,presence of stent in the stenotic segment,pre-stenosis degree,PTCA site,and bifurcation lesion(P＞0.05).The study group had a significantly higher prevalence of family history of coronary heart disease and noncompliance with medication compared to the control group,with statistical significance(P＜0.05).Multi-variate logistic regression analysis showed that DCB diameter,family history of coronary heart disease,and noncompliance with medication were independent risk factors for restenosis in the treatment of coronary mi-crovascular stenosis with DCB(P＜0.05).Conclusion In the treatment of coronary microvascular stenosis with DCB,a smaller DCB diameter(2.00-2.25 mm)is associated with a higher rate of restenosis.DCB diam-eter,family history of coronary heart disease,and noncompliance with medication are independent risk factors for restenosis in the treatment of coronary microvascular stenosis with DCB.
Drug coated balloonCoronary microvascular stenosisClinical controlled studyRest-enosisMultivariate logistic regression analysis
万方数据
维普
