The leukocyte Ig-like receptor subfamily B member 4(LILRB4)is an immunosuppressive receptor,which is expressed on monocytes,macrophages and dendritic cells under normal physiological condi-tions.The expression of LILRB4 in tumor cells,macrophages,natural killer cells and other immune cells in va-rious tumor tissues was higher than that in corresponding normal tissues,which could affect the biological be-havior of tumor cells and tumor immune microenvironment,and significantly promote tumor progression.Tumor immunotherapy targeting LILRB4 has shown good efficacy.This article reviewed the expression and role of LILRB4 in hematological and solid tumors,as well as the strategies of targeting LILRB4 in the treat-ment of tumors.
关键词
白细胞免疫球蛋白样受体亚家族B成员4/肿瘤微环境/作用/机制/免疫治疗/综述
Key words
The leukocyte Ig-like receptor subfamily B member 4/Tumor microenvironment/Role/Mechanism/Immunotherapy/Review
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