Research progress of systemic inflammation loop in the prediction and treatment for post stroke cognitive impairment
Post stroke cognitive impairment(PSCI)is a common complication of stroke,which can sig-nificantly increase the mortality rate of patients,reduce the 5-year survival rate of patients,and seriously affect the quality of life of patients.Up to now,the pathogenesis of PSCI is still unclear,so there is a lack of effective treatment Inflammation is a hot spot in PSCI research.Previous studies have shown that inflammatory mark-ers and inflammatory cells are related to cognitive decline,but how inflammation induces and exacerbates PS-CI remains unclear.This review put forward the theory that the pathogenesis of PSCI is related to systemic chronic inflammation,intestinal system inflammation,and central nervous system inflammation.There is a gradient inflammation loop among the three,which affect each other.The systemic inflammation loop for PS-CI could be a breakthrough for predicting and treating PSCI.
Post stroke cognitive impairmentSystemic chronic inflammationIntestinal system inflammationCentral nervous inflammationInflammation loopReview
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维普
