Clinical value of angiopoietin-like protein 3 in predicting heart failure complicated by PCI in coronary heart disease
Objective To investigate the clinical value of angiopoietin-like protein 3(ANGPTL3)in pre-dicting heart failure(HF)after percutaneous coronary intervention(PCI)in coronary heart disease.Methods A to-tal of 128 patients with coronary heart disease treated with PCI from January 2020 to January 2022 were in-cluded in the study.According to whether the patients were complicated by HF during the one-year follow-up period after surgery,they were divided into the HF group(41 cases)and the HF-free group(87 cases),and 30 healthy patients were selected for the control group.Serum samples were collected from each group,and the serum ANGPTL3 levels of each group were detected and compared by enzyme-linked immuno sorbent assay.Cardiac function related indicators[left ventricular end-diastolic diameter(LVESD),left atrial diameter(LAD),left ventricular posterior wall thickness(LVPW),and left ventricular ejection fraction(LVEF)]were measured by echocardiography.Pearson correlation analysis was used to analyze the correlation between AN-GPTL3 and cardiac function-related indexes,and the ROC curve was used to analyze the clinical value of ser-um ANGPTL3 in predicting HF complicated after PCI in coronary heart disease.Results There was signifi-cant difference in serum ANGPTL3 levels among the three groups(P＜0.001).Compared with the control group,the serum levels of ANGPTL3 in the patients with HF and without HF were higher,with statistical significance(P＜0.001).Compared with the HF-free group,the serum level of ANGPTL3 in the patients with HF was higher,and the measured values of LVESD,LAD and LVPW were higher,while the measured values of LVEF were lower,and the differences were statistically significant(P＜0.001).Pearson correlation analysis showed that the expression level of serum ANGPTL3 was positively correlated with New York Heart Associ-ation cardiac function classification,LVESD,LAD and LVPW(P＜0.001),but negatively correlated with LVEF(P＜0.001).The ROC curve analysis showed that the area under the curve of serum ANGPTL3 for predicting HF after PCI was 0.803(95％confidence interval 0.684-0.935,P＜0.001),the diagnostic cutoff value was 41.27 g/L,the sensitivity was 91.32％,the specificity was 73.29％,and the Youden index was 0.647.Conclusion ANGPTL3 expression in serum of patients with coronary heart disease complicated with HF is increased.Its expression level is related to the patient's cardiac function.It will become an evaluation index for HF complicated by PCI after coronary heart disease surgery.
Angiopoietin-like protein 3Coronary heart diseasePercutaneous coronary interven-tionHeart failureClinical value
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