Clinical efficacy of Yiqi Huoxue Huayu Decoction combined with dapagliflozin in treatment of type 2 diabetes mellitus complicated with chronic heart failure
Objective To investigate the efficacy of Yiqi Huoxue Huayu Decoction combined with dapa-gliflozin in the treatment patients with of type 2 diabetes mellitus(T2DM)complicated with chronic heart fail-ure(CHF)and its effects on blood glucose control,cardiac function,inflammatory factors and oxidative stress.Methods A total of 116 T2DM patients complicated with CHF admitted to Xinzheng Public People's Hospital from June 2022 to December 2023 were selected and divided into the traditional Chinese medicine(TCM)com-bination group and the dapagliflozin group by random number table method,with 58 cases in each group.The dapagliflozin group was treated with dapagliflozin,and the TCM combination group was treated with Yiqi Huoxue Huayu Decoction combined with dapagliflozin.After eight weeks of treatment,the clinical efficacy,blood glucose control[fasting blood glucose(FBG),2 h postmeal blood glucose(2 hPG),glycated hemoglobin(HbA1c)level],cardiac function indexes[heart rate,left ventricular ejection fraction(LVEF),6 min walking distance,N-terminal B-type natriuretic peptide(NT-proBNP)]and inflammatory factors[interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)],oxidative stress indexes[ma-londialdehyde(MDA),nitric oxide(NO),catalase(CAT),superoxide dismutase(SOD)].Results After 8 weeks of treatment,the total clinical effective rate of TCM combination group was 96.55％(56/58),which was higher than 84.48％(49/58)of the dapagliflozin group,and the difference was statistically significant(P＜0.05).After 8 weeks of treatment,the levels of FBG,2 hPG,HbA1c,heart rate and plasma NT-proBNP in the TCM combination group were lower than those in the dapagliflozin group,while LVEF and 6 min walk-ing distance were higher than those in dapagliflozin group,the differences were statistically significant(P＜0.05).After 8 weeks of treatment,the serum levels of IL-6,hs-CRP,TNF-α and MDA in the TCM combina-tion group were lower than those in the dapagliflozin group,and the serum levels of NO,CAT and SOD were higher than those in the dapagliflozin group,with statistical significance(P＜0.05).During the treatment,the total incidence of adverse reactions in the TCM combination group was 6.90％(4/58),which was slightly low-er than 13.79％(8/58)in the dapagliflozin group,but with no statistical significance(P＞0.05).Conclusion Yiqi Huoxue Huayu Decoction combined with dapagliflozin has a significant effect in the treatment of T2DM pa-tients with CHF,which can effectively regulate blood glucose,improve cardiac function,alleviate oxidative stress and reduce inflammation,with high safety.
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