运动疗法对脑出血神经保护作用机制的研究进展
Research progress on the neuroprotective mechanism of exercise therapy on cerebral hemorrhage
李明暇 1曹建洋 1汤鲁滨 2陈贵全 3杨国强3
作者信息
- 1. 西南医科大学体育学院,四川 泸州 646000
- 2. 四川科技职业学院,四川成都 611745
- 3. 西南医科大学附属中医医院针灸推拿康复科,四川 泸州 646000
- 折叠
摘要
脑出血(ICH)是一种严重危害人类健康的疾病,ICH后的功能障碍带来较高的致残率,已成为一个严重的公共卫生问题.因此,探索有效预防和治疗ICH的康复方法至关重要.运动疗法改善ICH后功能障碍的有效性显而易见,可促进血管生成、神经再生和突触可塑性,减轻ICH后的炎症反应、氧化应激和细胞凋亡发挥神经保护作用.然而,运动疗法在ICH中发挥神经保护作用的分子机制仍然未知.因此,该文通过回顾运动疗法防治ICH的临床和动物实验证据,以期揭示运动疗法潜在的神经保护机制,为运动疗法在ICH功能康复领域提供一定的理论依据.
Abstract
Intracerebral hemorrhage(ICH)is a serious disease that endangers human health.Dysfunc-tion after ICH brings a high disability rate and has become a serious public health problem.Therefore,it is very important to explore effective rehabilitation methods for the prevention and treatment of ICH.The effec-tiveness of exercise therapy in improving dysfunction after ICH is obvious.It can promote angiogenesis,nerve regeneration and synaptic plasticity,and reduce inflammatory response,oxidative stress and apoptosis after ICH to play a neuroprotective role.However,the molecular mechanism by which exercise therapy plays a neu-roprotective role in ICH remains unknown.Therefore,this article reviewed the clinical and animal experimen-tal evidence of exercise therapy in the prevention and treatment of ICH,in order to reveal the potential neuro-protective mechanism of exercise therapy,and provide a theoretical basis for exercise therapy in the field of ICH functional rehabilitation.
关键词
脑出血/运动疗法/神经保护/康复/机制/综述Key words
Cerebral hemorrhage/Exercise therapy/Neuroprotection/Rehabilitation/Mecha-nism/Review引用本文复制引用
基金项目
四川省科技计划联合创新专项项目(2022YFS0613-B3)
泸州市科技计划项目(2022-JY1-149)
西南医科大学校级科研项目(2021ZKQN125)
出版年
2024
国家科技期刊平台
NSTL
万方数据