Changes of serum homocysteine,folic acid and vitamin B12 levels in pregnant women during different pregnancy periods in Guiyang area and their effects on the outcome of offspring
Objective To understand the levels of serum homocysteine(Hcy),folic acid(FA)and vita-min B12(VitB12)in pregnant women during different pregnancy periods in Guiyang area and their effects on adverse outcomes of offspring,so as to provide reference for individualized supplementation of FA and VitB12 in pregnant women,prevention of pregnancy complications and fetal birth defects.Methods From January to December 2022,a total of 400 pregnant women with singleton pregnancy were selected from the obstetrics clinic of Guizhou Provincial People's Hospital.Among them,50 pregnant women with adverse fetal outcomes were selected as the observation group,and 350 pregnant women with normal fetal outcomes were selected as the control group.The observation group and the control group were divided into early pregnancy group,mid-dle pregnancy group and late pregnancy group according to different gestational weeks.Another 100 healthy non-pregnant women of childbearing age who underwent physical examination in the hospital during the same period were selected as the healthy group.The levels of Hcy,FA and VitB12 were detected by enzyme circula-tion method and chemiluminescence microparticle immunoassay.The changes of serum Hcy,FA and VitB12 levels in the three groups were compared.The regression analysis of serum Hcy,FA and VitB12 was carried out by Pearson linear correlation,and the related risk factors of adverse fetal outcomes were analyzed by un-conditional logistic multiple stepwise regression.Results The levels of serum Hcy,FA and VitB12 in the ob-servation group and the control group were significantly higher than those in the healthy group,and the levels of FA and VitB12 were significantly lower than those in the healthy group,the differences were statistically significant(P<0.05).The levels of serum Hcy,FA and VitB12 in the observation group were significantly higher than those in the control group,while the levels of FA and VitB12 were lower than those in the control group,the differences were statistically significant(P<0.05).The levels of serum Hcy,FA and VitB12 in pregnant women decreased gradually with the increase of gestational age.Pearson correlation analysis showed that serum Hcy was negatively correlated with FA(r=-0.772,P<0.05).Serum Hcy was negatively corre-lated with VitB12(r=-0.613,P<0.05).There was a positive correlation between FA and VitB12(r=0.568,P<0.05).The results of unconditional logistic multiple stepwise regression showed that the increase of Hcy level,the decrease of FA level and the decrease of VitB12 level were all risk factors for adverse fetal outcomes in pregnant women(P<0.05).Conclusion The levels of serum Hcy,FA and VitB12 in pregnant women are closely related to the occurrence of adverse fetal outcomes.Therefore,the monitoring of these indicators should be strengthened during pregnancy,and intervention measures should be taken once abnormalities are found to reduce the risk of adverse fetal outcomes.
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