Analysis effect and factors of serum uric acid on renal function in male officers and soldiers aged 19-<30 years old
Objective To explore the effect of serum uric acid(SUA)on glomerular filtration rate(eG-FR)and related factors in male soldiers aged 19-<30 years,and to provide a theoretical basis for ensuring the health of soldiers.Methods The age,body mass index(BMI)and biochemical indexes of male soldiers who underwent physical examination in the this hospital in 2022 were collected and statistically analyzed.Re-sults Compared with other age groups,the highest detection rates of SUA concentration and hyperuricemia were found in officers and soldiers aged 19-<30(P≤0.001);SUA and eGFR were negatively correlated in this age group(r=-0.24,P<0.001);ROC analysis showed that SUA concentration had a predictive value of impaired eGFR(AUC=0.661),and the rate of eGFR impairment increased significantly when SUA was grea-ter than 503 μmol/L and the rate of eGFR impairment was significantly increased at SUA greater than 503 μmol/L.Regression analysis showed that SUA(corrected OR=1.003,95%CI 1.001-1.006,P=0.018)and low-density lipoprotein cholesterol(LDL-C)(corrected OR=1.585,95%CI 1.145-2.193,P=0.005)were in-dependent risk factors for eGFR impairment.Mediation effect analysis found that LDL-C mediated 49.39%of the effect of SUA leading to eGFR impairment.Conclusion The detection rate of HUA is high in male sol-diers aged 19-<30 years in the army.SUA and LDL-C are independent risk factors for eGFR damage.Reduc-ing LDL-C may prevent renal damage caused by HUA.
Young officers and soldiersSerum uric acidEstimated glomerular filtration rateLow-density lipoprotein cholesterol
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