Study on the relationship between Pan-immune inflammatory index and hypercoagulable state in patients with idiopathic membranous nephropathy
Objective To investigate the relationship between Pan-immune inflammation Value(PIV)and hypercoagulable state in patients with idiopathic membranous nephropathy(IMN).Methods Clinical data of 280 patients diagnosed with IMN idiopathic membranous nephropathy who underwent renal biopsy at the Department of Nephrology,Affiliated Hospital of Xuzhou Medical University from February 2020 to February 2021 were retrospectively analyzed.Patients were categorized into the hypercoagulable group(89 cases)and the control group(191 cases)based on criteria for hypercoagulability,and baseline clinical data between the two groups were compared.Results Binary logistic regression analysis revealed that PIV level(OR=1.002,95%CI 1.000-1.004,P=0.016),total cholesterol(OR=1.398,95%CI 1.190-1.642,P<0.001),and an-tithrombin Ⅲ activity(OR=0.903,95%CI 0.871-0.936,P<0.001)were independent risk factors for hy-percoagulable state in IMN patients.Conclusion PIV is an independent risk factor for hypercoagulable state in patients with IMN.Early assessment of PIV levels in IMN patients with higher PIV levels can aid in evalua-ting their coagulation status and initiating preventive measures such as anticoagulation therapy.
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