β-烟酰胺单核苷酸及其在维持基因组稳态中的研究进展
Research progress of β-nicotinamide mononucleotide and its role in maintaining genomic homeostasis
魏明臣 1牛梦伟 2宋英杰 2韩尧 2李浩 2孙岩松1
作者信息
- 1. 牡丹江医学院公共卫生学院,黑龙江 牡丹江 157000;中国人民解放军军事科学院军事医学研究院,北京 100071
- 2. 中国人民解放军军事科学院军事医学研究院,北京 100071
- 折叠
摘要
β-烟酰胺单核苷酸(NMN)是辅酶Ⅰ烟酰胺腺嘌呤二核苷酸(NAD+)的前体,其主要通过NAD+在细胞生命过程中发挥关键作用,包括DNA损伤修复信号通路、氧化还原反应和代谢反应等.补充NMN提高细胞内NAD+水平以增强DNA损伤修复,已成为国内外研究的焦点.该文综述了NMN在延缓衰老、治疗疾病、维持基因组稳定性及细胞稳态方面的最新研究进展,分析了其提升宿主DNA损伤修复能力的作用机制,并对补充NMN的潜在风险进行探讨,为后续的NMN相关科学研究提供参考.
Abstract
β-nicotinamide mononucleotide(NMN)is the precursor of coenzyme Ⅰ nicotinamide adenine dinucleotide(NAD+),which plays a crucial role in complicated cellular processes,including DNA damage sig-naling pathways,redox reaction,and metabolic reaction.Supplementation of NMN to increase concentration of intracellular NAD+and enhance the capacity of DNA damage repair has become a spot of research worldwide.This review provided an overview of latest research advancements in NMN,focusing on its potential in dela-ying aging,treating diseases,maintaining genomic stability,and cellular homeostasis.The mechanism of NMN's enhancement of host DNA damage repair ability was analyzed,and the potential risks of supplemen-ting NMN were discussed to provide reference for subsequent NMN-related scientific research.
关键词
β-烟酰胺单核苷酸/DNA损伤修复/烟酰胺腺嘌呤二核苷酸/多聚二磷酸腺苷核糖聚合酶/去乙酰化酶Key words
β-nicotinamide mononucleotide/Repair of DNA damage/nicotinamide adenine dinucle-otide/Poly ADP-Ribose Polymerase/Sirtuin引用本文复制引用
基金项目
国家自然科学基金项目(31901051)
国家科技重大专项课题(2018ZX10301-407)
出版年
2024
国家科技期刊平台
NSTL
万方数据