Research progress of β-nicotinamide mononucleotide and its role in maintaining genomic homeostasis
β-nicotinamide mononucleotide(NMN)is the precursor of coenzyme Ⅰ nicotinamide adenine dinucleotide(NAD+),which plays a crucial role in complicated cellular processes,including DNA damage sig-naling pathways,redox reaction,and metabolic reaction.Supplementation of NMN to increase concentration of intracellular NAD+and enhance the capacity of DNA damage repair has become a spot of research worldwide.This review provided an overview of latest research advancements in NMN,focusing on its potential in dela-ying aging,treating diseases,maintaining genomic stability,and cellular homeostasis.The mechanism of NMN's enhancement of host DNA damage repair ability was analyzed,and the potential risks of supplemen-ting NMN were discussed to provide reference for subsequent NMN-related scientific research.
β-nicotinamide mononucleotideRepair of DNA damagenicotinamide adenine dinucle-otidePoly ADP-Ribose PolymeraseSirtuin
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