机械敏感性离子通道蛋白Piezo1与临床疾病相关性的研究进展
Research progress on the relationship between mechanosensitive ion channel protein Piezo1 and clinical diseases
郝晓蓓 1王庆 1陈俊羽 1翁恒 1杨敏 1潘娅岚 1徐桂华1
作者信息
- 1. 南京中医药大学护理学院,江苏 南京 210023
- 折叠
摘要
Piezo1蛋白作为一种与机械应力刺激信号密切相关的新型机械敏感性离子通道,在响应机械刺激和运动效应方面作用显著.该蛋白在机体的器官和组织中分布广泛、作用较大,自被发现以来,受到了学界的广泛关注.大量科学研究表明,Piezo1在血管、神经、骨骼、免疫、肿瘤等疾病的治疗方面均具有重要意义.该文对Piezo1生物学特性及其与临床疾病的相关性进行综述,为临床相关疾病的发病机制、诊断、治疗和预后监测研究提供了新的思路和展望.
Abstract
Piezo1 protein,as a novel mechanosensitive ion channel closely related to mechanical stress stimulation signals,plays a significant role in responding to mechanical stimulation and motion effects.This protein is widely distributed in the organs and tissues of the body,and has been widely concerned by the aca-demic community since its discovery.A number of highly successful scientific studies have shown that Piezo1 has important implications for the treatment of vascular,neurological,skeletal,immune,tumor and other dis-eases.Therefore,this paper reviewed the biological characteristics of Piezo1 and its correlation with clinical diseases,which provides new ideas and prospects for the study of the pathogenesis,diagnosis,treatment and prognosis monitoring of clinically related diseases.
关键词
Piezo1/功能/临床疾病/机械力/蛋白/综述Key words
Piezo1/Function/Clinical disease/Mechanical force/Protein/Review引用本文复制引用
基金项目
国家自然科学基金项目(82205237)
江苏省中医药科技发展计划项目(YB2020004)
2021年度江苏省卫生健康委医学科研项目指导性项目(Z2021065)
江苏省高校哲学社会科学研究项目(2024SJYB0248)
出版年
2024
国家科技期刊平台
NSTL
万方数据