Research progress of vitamin D and polycystic ovary syndrome
Polycystic ovary syndrome(PCOS)is a common gynecological endocrine disorder character-ized by anovulation or oligo-ovulation.Its etiology is associated with hyperandrogenism,insulin resistance,and lipid metabolism abnormalities,but the exact mechanism is not yet clear.Vitamin D is a steroid hormone in-volved in calcium metabolism and bone structure.Reports indicate that vitamin D receptors can be detected in granulosa cells and theca cells of animal and human ovarian tissues,and vitamin D deficiency is a common complication of PCOS,with vitamin D levels being associated with the fertility,metabolic changes,and psycho-logical health of PCOS patients.Some studies have found that the degree of vitamin D deficiency is related to the severity of PCOS.Although the etiology of PCOS is not yet clear,drug treatments are often ineffective,and relapse is common after discontinuation.However,in recent years,research has suggested that combined treatment with vitamin D and hormonal drugs can significantly improve clinical symptoms of PCOS,particu-larly benefiting follicular development and restoration of ovulation.Nevertheless,there are also some conflict-ing views in the literature.Therefore,it is necessary to comprehensively review vitamin D and its potentially related calcium ion channels.
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