Effect of serum vitamin D levels on HIV-1 infected individuals
Objective To investigate the influence of serum vitamin D levels on individuals infected with human immunodeficiency virus type 1(HIV-1).Methods A total of 411 treated HIV-1 infected patients undergoing HIV-1 DNA testing at the First Hospital of Changsha from January 2021 to July 2023 were in-cluded.Among them,92 infected individuals with vitamin D deficiency were subjected to supplementary test and divided into study group(42 cases)and control group(50 cases)according to voluntary basis.Analysis in-cluded assessment of vitamin D deficiency across different demographic and clinical characteristics of HIV-1 infected individuals,comparison of serum vitamin D levels,T-cell subset levels,and HIV-1 DNA levels be-tween the two groups,and correlation analysis of serum vitamin D levels with T-cell subsets and HIV-1 DNA levels.Results Significant differences in serum vitamin D deficiency rates were observed among HIV-1 infec-ted individuals across different age groups,antiretroviral therapy(ART)durations,CD8+T-cell counts,and CD4/CD8 ratios(P＜0.05).Individuals aged ≥40 years exhibited significantly lower rates of vitamin D defi-ciency compared to those aged＜40 years(P＜0.05).Serum vitamin D levels were negatively correlated with CD8+T-cell counts(r=-0.251 0,P＜0.05),positively correlated with CD4/CD8 ratios(r=0.172 6,P＜0.05),and showed no significant correlation with CD4+T-cell counts(P＞0.05).Serum vitamin D levels were negatively correlated with HIV-1 DNA levels(r=-0.102 2,P＜0.05)and positively correlated with ART duration(r=0.127 4,P＜0.05).There were no statistically significant differences in baseline serum vitamin D levels and T-cell subset levels between the study and control groups(P＞0.05).At the 48-week follow-up,the study group showed significantly higher levels of serum vitamin D,CD4+T-cell counts,and CD8+T-cell counts compared to baseline(P＜0.05),whereas the control group exhibited only higher serum vitamin D lev-els compared to baseline(P=0.007).Comparison of CD4+T-cell counts,CD8+T-cell counts,and CD4/CD8 ratios between the two groups at 48 weeks did not show statistically significant differences(P＞0.05).At the 48-week follow-up,the study group had significantly higher serum vitamin D and CD8+T-cell counts com-pared to the control group(P＜0.05).Conclusion Younger individuals and those in early stages of ART with HIV-1 infection tend to have relatively lower serum vitamin D levels.Supplementation with vitamin D3 may improve immune function and reduce viral reservoir levels.
Human immunodeficiency virusVitamin DImmune functionViral repository
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维普
