Survival analysis of patients with malignant peritoneal mesothelioma based on SEER database
Objective To analyze the survival outcomes and prognostic factors of patients with malig-nant peritoneal mesothelioma(MPM)based on the Surveillance,Epidemiology,and End Results(SEER)data-base.Methods A retrospective analysis of demographic characteristics,clinicopathological data,and cancer-specific survival(CSS)rates of the patients diagnosed with MPM from 2004 to 2017 in the SEER database was conduc-ted.Prognostic factors were assessed using univariate and multivariate Cox regression analyses.Results Among 516 MPM patients,the 1-,3-,and 5-year CSS rates were 55.7％,32.9％,and 27.6％,respectively.Univariate Cox regression analysis of 95 MPM patients indicated that age ≥65 years,male sex,sarcomatoid subtype,moderate differentiation,poor differentiation,undifferentiated tumors,distant metastasis,and absence of surgery were significant risk factors affecting patient survival(P＜0.05).Comparison of cumulative survival rates among MPM patients stratified by different ages,sexes,histological subtypes,pathological grades,SEER stage,and surgical status showed statistically significant differences(P＜0.05).Multivariate Cox regression analysis re-vealed that sarcomatoid subtype(P=0.036),moderate differentiation(P=0.012),poor differentiation(P＜0.001),undifferentiated tumors(P＜0.001),distant metastasis(P=0.005),and chemotherapy(P=0.010)were independent adverse prognostic factors for the MPM patients.Conclusion Prognosis of MPM patients is associated with tumor histological subtype,pathological grade,SEER stage,and chemotherapy status.
万方数据
维普
