Objective To explore the clinical value of four-dimensional ultrasound combined with transabdominal echocardiography in the screening of fetal congenital heart disease.Methods A total of 2 013 pregnant women who underwent prenatal screening in the hospital from April 2020 to April 2023 were selected for four-dimensional ultrasound and transabdominal echocardiography.The results of postnatal echocardiography or autopsy after induction of labor were used as the"gold standard"to analyze the efficacy of four-dimensional ultrasound and transabdominal echocardiography in screening fetal congenital heart disease.Results Among the 2 013 pregnant women,56 cases were confirmed to have congenital heart disease by the"gold standard",while 46 cases were detected by transabdominal echocardiography,48 cases were detected by four-dimensional echocardiography,and 55 cases were detected by the combination of the two.The sensitivity,accuracy and neg-ative predictive value of four-dimensional ultrasound and transabdominal echocardiography in screening fetal congenital heart disease were lower than those of the combined screening,and the differences were statistically significant(P＜0.05).The screening results of four-dimensional ultrasound combined with transabdominal echocardiography were in excellent agreement with the results of the"gold standard"(kappa value=0.972,P＜0.001).The accuracy of four-dimensional ultrasound and transabdominal echocardiography in screening atrial septal defect was lower than that of the combined screening,and the difference was statistically signifi-cant(P＜0.05).Conclusion Four-dimensional ultrasound combined with transabdominal echocardiography has high sensitivity and accuracy,and can more effectively screen fetal congenital heart disease,especially atrial septal defect.
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