Effect of video-assisted thoracoscopic surgery on immune function and inflammatory factor levels in patients with non-small cell lung cancer
Objective To investigate the effect of video-assisted thoracoscopic surgery(VATS)on im-mune function and inflammatory factors in patients with non-small cell lung cancer(NSCLC).Methods A to-tal of 60 patients with NSCLC admitted to our hospital from July 2020 to June 2022 were selected and divided into the observation group(30 cases)and the control group(30 cases)according to the random number table method.The control group was treated with thoracotomy,and the observation group was treated with VATS.The operation-related indexes,immune function indexes[CD4+,CD8+,CD4-/CD8+ratio,immunoglobulin(Ig)G,IgA,IgM],inflammatory factors[C-reactive protein(CRP),interleukin-2 receptor(IL-2R),matrix met-alloproteinase-9(MMP-9)],incidence of complications and 1-year survival rate were compared between the two groups.Results The intraoperative blood loss and intraoperative blood transfusion in the observation group were lower than those in the control group,and the operation time and hospitalization time were shorter than those in the control group,the differences were statistically significant(P＜0.05).There was no signifi-cant difference being found in the comparison of the number of N2 lymph nodes and lymph node dissection be-tween the two groups(P＞0.05).There was no significant difference being found in the comparison of the im-mune function indexes between the two groups before treatment(P＞0.05).The immune function indexes of the two groups after treatment were lower than those before treatment,and the difference was statistically significant(P＜0.05).The CD4+/CD8+ratio and the levels of CD4+,IgG,IgA and IgM in the observation group were higher than those in the control group,and the CD8+level was lower than that in the control group,the differences were statistically significant(P＜0.05).There was no significant difference being found in the comparison of the levels of inflammatory factors between the two groups before treatment(P＞0.05).After treatment,the levels of IL-2R,CRP and MMP-9 in the two groups were higher than those before treat-ment,and the levels of each index in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of complications and 1-year survival rate between the two groups(P＞0.05).Conclusion VATS can shorten the operation time and hospitalization time of NSCLC patients,reduce the amount of intraoperative blood loss and the level of inflammatory factors,and has little effect on immune function.
万方数据
维普
