Effect of serum VEGF,IGF-1 and NRG1 levels on first-episode schizophrenia patients
Objective To explore the effects of vascular endothelial growth factor(VEGF),insulin-like growth factor 1(IGF-1)and neuromodulatory protein 1(NRG1)on first-episode schizophrenia patients.Meth-ods A total of 71 patients with first-episode schizophrenia admitted to the hospital from September 2021 to January 2023 were retrospectively selected as the study group,and 71 healthy volunteers who underwent phys-ical examination during the same period were selected as the control group.At the same time,according to the results ofpositive and negative symptom scale(PANSS)score results,the study group was divided into the high score subgroup(≥70 points,33 cases)and the low score subgroup(＜70 points,38 cases).The study group was divided into cognitive dysfunction group(29 cases)and normal cognitive function group(42 cases)according to the results of MATRICS recognized cognitive battery(MCCB).The levels of serum VEGF,IGF1,and NRG1 in each group were compared,and their correlation with MCCB and PANSS scores was analyzed.Results The levels of serum VEGF,IGF1,and NRG1 in the study group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The levels of serum VEGF,IGF1,and NRG1 in the cognitive dysfunction subgroup were lower than those in the normal cognitive function sub-group,and the differences were statistically significant(P＜0.05).The levels of serum VEGF,IGF1,and NRG1 in the low score subgroup were higher than those in the high score subgroup,and the differences were statistically significant(P＜0.05).The levels of serum VEGF,IGF1,and NRG1 were positively correlated with MCCB and PANSS scores(P＜0.05).Conclusion The levels of serum VEGF,IGF1 and NRG1 in pa-tients with schizophrenia are lower than those in healthy people,which are closely related to mental symptoms and cognitive function.
万方数据
维普
