现代医药卫生2024,Vol.40Issue(15) :2624-2630.DOI:10.3969/j.issn.1009-5519.2024.15.023

糖尿病肾病中细胞焦亡发生机制及中医药干预研究进展

Research progress on mechanism of pyroptosis in diabetes nephropathy and intervention of traditional Chinese medicine

李清 王乐 张晓艳 陈雅婷 张梓茹 赵静
现代医药卫生2024,Vol.40Issue(15) :2624-2630.DOI:10.3969/j.issn.1009-5519.2024.15.023

糖尿病肾病中细胞焦亡发生机制及中医药干预研究进展

Research progress on mechanism of pyroptosis in diabetes nephropathy and intervention of traditional Chinese medicine

李清 1王乐 2张晓艳 3陈雅婷 2张梓茹 2赵静2
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作者信息

  • 1. 河北医科大学中西医结合学院,河北 石家庄 050017;河北中医药大学中药药理教研室,河北 石家庄 050200
  • 2. 河北医科大学中西医结合学院,河北 石家庄 050017
  • 3. 河北省中医院脾胃三科,河北 石家庄 050000
  • 折叠

摘要

细胞焦亡是糖尿病肾病(DKD)发生发展中的重要环节,其引发的炎症和细胞损伤与肾纤维化、肾小球硬化及肾小管损伤有密切关联.深入研究细胞焦亡和炎性小体信号通路的潜在分子机制可能成为预防和治疗DKD的一种新的途径.中医药防治DKD的临床效果显著,其通过影响细胞焦亡通路发挥保护作用.该文对细胞焦亡与DKD的分子机制研究及中医药干预的研究进展进行了综述,为进一步探索细胞焦亡致病机理及中药治疗DKD提供重要指导.

Abstract

Pyroptosis is an important link in the development of diabetes nephropathy(DKD).The in-flammation and cell damage caused by it are closely related to renal fibrosis,glomerulosclerosis and tubular damage.In depth research on the potential molecular mechanisms of pyroptosis and inflammasome signaling pathways may become a new approach for the prevention and treatment of DKD.The clinical effect of tradi-tional Chinese medicine in preventing and treating DKD is significant,as it exerts a protective effect by affect-ing the cell pyroptosis pathway.The article reviews the molecular mechanisms of cell pyroptosis and DKD,as well as the research progress in traditional Chinese medicine intervention,providing important guidance for further exploration of the pathogenic mechanism of cell pyroptosis and the treatment of DKD with traditional Chinese medicine.

关键词

细胞焦亡/糖尿病肾病/中医药/综述

Key words

Pyroptosis/Diabetes nephropathy/Traditional Chinese Medicine/Review

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基金项目

河北省中医药管理局项目(2018114)

河北省卫生健康委员会医学科学研究课题计划项目(20220970)

河北医科大学大学生创新性实验计划项目(USIP2022147)

河北医科大学大学生创新性实验计划项目(USIP2023122)

出版年

2024
现代医药卫生
重庆市卫生信息中心

现代医药卫生

影响因子:0.758
ISSN:1009-5519
参考文献量20
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