Research progress on mechanism of pyroptosis in diabetes nephropathy and intervention of traditional Chinese medicine
Pyroptosis is an important link in the development of diabetes nephropathy(DKD).The in-flammation and cell damage caused by it are closely related to renal fibrosis,glomerulosclerosis and tubular damage.In depth research on the potential molecular mechanisms of pyroptosis and inflammasome signaling pathways may become a new approach for the prevention and treatment of DKD.The clinical effect of tradi-tional Chinese medicine in preventing and treating DKD is significant,as it exerts a protective effect by affect-ing the cell pyroptosis pathway.The article reviews the molecular mechanisms of cell pyroptosis and DKD,as well as the research progress in traditional Chinese medicine intervention,providing important guidance for further exploration of the pathogenic mechanism of cell pyroptosis and the treatment of DKD with traditional Chinese medicine.
PyroptosisDiabetes nephropathyTraditional Chinese MedicineReview