Research progress on the regulation of Wnt signaling pathway by traditional Chinese medicine in the treatment of myocardial ischemia-reperfusion injury
At present,the incidence rate of acute myocardial infarction is increasing year by year.Pa-tients with acute myocardial infarction may experience myocardial ischemia-reperfusion injury(MIRI)after reperfusion of coronary blood flow,which further exacerbates the injury and leads to a decrease in the patient's quality of life.Therefore,reducing MIRI has become one of the urgent issues that need to be addressed in the treatment of cardiovascular diseases.Traditional Chinese medicine has the advantages of multiple pathways and targets in the treatment of MIRI,which can provide new ideas for alleviating MIRI.The Wnt signaling pathway is closely related to the occurrence and development of MIRI,and it can improve MIRI by regulating inflammatory response,cell apoptosis,oxidative stress,autophagy,and other factors.The article reviews the research progress of traditional Chinese medicine in alleviating MIRI by regulating the Wnt signaling path-way,in order to provide a theoretical basis for the treatment of MIRI.
Wnt signaling pathwayTraditional Chinese MedicineMyocardial ischemia-reperfu-sion injuryReview
万方数据
维普
