摘要
血脂对维持正常的生理稳态至关重要,血脂水平与心血管疾病及癌症的发生、发展和转移密切相关.他汀类药物是常用于调节血脂、抵抗炎症、保护血管内皮和抗血小板凝聚等方面的药物,其抗肿瘤功效和作用也正受到广泛关注.该文对血脂水平与4种常见肿瘤的关系,以及他汀类药物调节血脂水平、抗肿瘤的作用机制进行了综述.他汀类药物在发挥调节血脂水平作用的同时,有望作为肿瘤药物在肿瘤治疗中发挥更大的作用.
Abstract
Blood lipids are crucial for maintaining normal physiological homeostasis,and their levels are closely related to the occurrence,development,and metastasis of cardiovascular diseases and cancer.Statins are commonly used drugs to regulate blood lipids,resist inflammation,protect vascular endothelium,and prevent platelet aggregation.Their anti-tumor effects and effects are also receiving widespread attention.The article reviews the relationship between blood lipid levels and four common tumors,as well as the mechanisms of sta-tin drugs in regulating blood lipid levels and anti-tumor effects.Statins have the potential to play a greater role as tumor drugs in tumor treatment,while also regulating blood lipid levels.
基金项目
重庆医科大学未来医学青年创新团队支持计划项目(W0188)
维普
万方数据