现代医药卫生2024,Vol.40Issue(16) :2723-2726,2731.DOI:10.3969/j.issn.1009-5519.2024.16.005

伴多种并发症的Ⅰ型自身免疫性多内分泌腺病综合征1例及文献复习

A case of type Ⅰ autoimmune polyendocrinopathy syndrome with multiple complications and review of the literature

和彩玲 赵蓉 尹虹 王百灵
现代医药卫生2024,Vol.40Issue(16) :2723-2726,2731.DOI:10.3969/j.issn.1009-5519.2024.16.005

伴多种并发症的Ⅰ型自身免疫性多内分泌腺病综合征1例及文献复习

A case of type Ⅰ autoimmune polyendocrinopathy syndrome with multiple complications and review of the literature

和彩玲 1赵蓉 1尹虹 1王百灵1
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作者信息

  • 1. 甘肃省兰州市第一人民医院内分泌科,甘肃 兰州 730050
  • 折叠

摘要

该文报道了1例53岁中年女性患者的临床资料.患者因头晕、乏力、恶心、呕吐3 d及腹泻入院.临床检查显示该患者有多种自身免疫性及非免疫性疾病,并伴多种并发症.主要疾病包括口腔念珠菌感染、1型糖尿病、桥本甲状腺炎甲状腺功能减退、中重度非节段型白癜风.同时发现患者患代谢综合征,包括高密度脂蛋白缺乏、高血压病1级(极高危组)及糖尿病性酮症酸中毒、糖尿病性周围神经病变、糖尿病性肾病(G2A1期)、糖尿病性周围血管病变.此外,该患者还患有低蛋白血症、锁骨下动脉斑块、颈总动脉斑块、抑郁状态和骨质疏松等多种并发症,患者被临床诊断为Ⅰ型自身免疫性多内分泌综合征.患者经住院期间综合治疗恢复良好,出院后继续服药.

Abstract

This paper reports the clinical data of a 53-year-old middle-aged female patient who was ad-mitted to the hospital with dizziness,fatigue,nausea,vomiting for 3 days and diarrhea.The Clinical examina-tion showed that the patient had a variety of autoimmune and non-immune manifestations,accompanied by a variety of complications.The main disease are oral candida infection,type Ⅰ diabetes,Hashimoto thyroiditis hypothyroidism,and moderate to severe non-segmental vitiligo.At the same time,it was found that the patient had metabolic syndrome,including high-density lipoprotein deficiency,hypertension grade 1(very high risk group)and diabetic ketoacidosis,diabetic peripheral neuropathy,diabetic nephropathy(stage G2A1),and dia-betic peripheral vasculopathy.In addition,the patient had multiple complications such as hypoproteinemia,subclavian artery plaque,common carotid artery plaque,depressive status,and osteoporosis,and was clinically diagnosed as type Ⅰ autoimmune polyendocrine syndrome.The patient recovered well after comprehensive treatment during hospitalization and continued to take medication after discharge.

关键词

自身免疫性多内分泌综合征Ⅰ型/口腔念珠菌感染/甲状腺功能减退/Ⅰ型糖尿病/白癜风/病例报告/文献复习

Key words

Type Ⅰ autoimmune polyendocrinopathy syndrome/Oral candida infection/Hypothy-roidism/Type Ⅰ diabetes/Vitiligo/Case report/Literature review

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基金项目

2021年兰州市卫生健康科技发展项目(2021014)

2020年兰州市科技发展指导性计划项目(2020-zd-115)

出版年

2024
现代医药卫生
重庆市卫生信息中心

现代医药卫生

影响因子:0.758
ISSN:1009-5519
参考文献量2
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