20 Hz重复经颅磁刺激联合文拉法辛治疗成人广泛性焦虑障碍的效果研究
Study on the effects of 20 Hz repetitive transcranial magnetic stimulation combined with venlafaxine in the treatment of adult generalized anxiety disorders
楚孔渠 1甘景梨 1段惠峰 1梁学军1
作者信息
- 1. 中国人民解放军联勤保障部队第九八八医院全军精神疾病防治研究所,河南 焦作 454003
- 折叠
摘要
目的 观察20 Hz重复经颅磁刺激(rTMS)联合文拉法辛治疗成人广泛性焦虑障碍(GAD)的疗效及对认知功能和负性情绪的影响.方法 选取2021年3月至2023年4月该院收治的成人GAD患者75例,采用随机数字表法分为研究组(38例)和对照组(37例).对照组患者采用文拉法辛治疗,研究组患者则在文拉法辛治疗基础上联用rTMS治疗.对比2组患者临床疗效.结果 研究组患者总有效率、眼动测定、蒙特利尔认知评估量表评分均明显高于对照组,事件相关电位潜伏期,以及GAD-7量表、汉密尔顿焦虑量表、汉密尔顿抑郁量表评分均明显低于对照组,差异均有统计学意义(P<0.05).结论 20 Hz rTMS联合文拉法辛治疗能提高成人GAD患者的临床疗效,改善其认知功能,并缓解其负性情绪,治疗实用性较高.
Abstract
Objective To observe the effects of 20 Hz repetitive transcranial magnetic stimulation(rT-MS)combined with venlafaxine in the treatment of adult generalized anxiety disorder(GAD)and its impact on cognitive function and negative emotions.Methods A total of 75 adult patients with GAD admitted to the hospital from March 2021 to April 2023 were randomly divided into two groups using the random number ta-ble method.The control group(37 cases)received venlafaxine treatment,while the study group(38 cases)re-ceived rTMS on the basis of venlafaxine.The clinical efficacy of the two groups was compared.Results The total effective rate,eye movement measurement,Montreal Cognitive Assessment Scale(MoCA)scores in the study group were higher than those in the control group,and the event-related potential latency,as well as the scores of GAD-7 scale,Hamilton Anxiety Scale and Hamilton Depression Scale were significantly lower than those of the control group,with statistical significance(P<0.05).Conclusion The 20 Hz repetitive transcra-nial magnetic stimulation combined with venlafaxine therapy can improve the clinical efficacy,cognitive func-tion,and alleviate negative emotions in adult patients with GAD,with high therapeutic practicality.
关键词
重复经颅磁刺激/文拉法辛/成年人/广泛性焦虑障碍/认知功能/负性情绪Key words
Repetitive transcranial magnetic stimulation/Venlafaxine/Adult/Generalized anxie-ty disorder/Cognitive function/Negative emotions引用本文复制引用
基金项目
河南省医学科技攻关计划项目(LHGJ20200791)
出版年
2024
国家科技期刊平台
NSTL
万方数据