摘要
目的 探讨百乐眠胶囊联合氟哌噻吨美利曲辛片(黛力新)对睡眠障碍(SD)患者睡眠结构相关指标、睡眠质量及神经递质水平的影响.方法 将2022年1月至2023年9月该院收治的98例SD患者采用随机数字法分为观察组和对照组,每组49例.对照组给予黛力新治疗,观察组在黛力新治疗基础上给予百乐眠胶囊治疗,对比2组患者睡眠结构相关指标[包括睡眠潜伏期(SOL)、总睡眠时间(TST)和睡眠效率(SE)]、睡眠质量[匹兹堡睡眠质量指数(PSQI)评分]、神经递质水平[包括去甲肾上腺素(NE)、5-羟色胺(5-HT)和γ-氨基丁酸(GABA)]等.结果 2组患者治疗后SOL、PSQI评分、NE水平均明显降低,TST、SE均明显增加,5-HT、GABA水平均明显升高,且观察组患者治疗后SOL、TST、SE、PSQI评分,以及NE、5-HT、GABA水平均优于对照组,差异均有统计学意义(P<0.05).结论 百乐眠胶囊联合黛力新可调节SD患者神经递质水平,改善睡眠结构相关指标,提高睡眠质量.
Abstract
Objective To investigate the effect of Bailemien capsule combined with Delisin on sleep structure related indexes,sleep quality and neurotransmitter levels in patients with sleep disorders(SD).Methods A total of 98 SD patients treated in our hospital from January 2022 to September 2023 were divided into the control group and the observation group with 49 cases in each group by random number method.The control group was treated with Delisin,and the observation group was treated with Bailimian capsule on the basis of Delisin treatment.The sleep structure related indexes[including sleep onset latency(SOL),total sleep time(TST)and sleep efficiency(SE)],sleep quality[Pittsburgh Sleep Quality Index(PSQI)score],and neurotransmitter levels[including norepinephrine(NE),5-hydroxytryptamine(5-HT)and gamma-aminobu-tyric acid(GABA)]were compared between the two groups.Results After treatment,the SOL,PSQI scores and NE levels of the two groups were significantly decreased,TST and SE were significantly increased,5-HT and GABA levels were significantly increased,and the SOL,TST,SE and PSQI scores,as well as NE,5-HT and GA-BA levels of the observation group were superior to the control group after treatment.The differences were statistically significant(P<0.05).Conclusion Bailemien capsule combined with Delisin can regulate the level of neurotransmitter in SD patients,improve the related indexes of sleep structure and improve sleep quality.
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