Analysis of negative conversion after HPV infection by different treatment methods
Objective To choose different treatment methods after human papillomavirus(HPV)infec-tion,and analyze the negative conversion of HPV,so as to provide reference for the treatment after HPV in-fection.Methods From January 2016 to October 2023,a total of 278 cases(1109 HPV genotyping reports)of the women who had positive HPV genotyping tests in outpatient,inpatient,and health examinations in the hospital were selected as the research objects.The patients diagnosed as cervical cancer,cervical intraepithelial neoplasia or inflammation by biopsy after HPV infection were treated with surgery(the operation group,40 cases),medicine(the medication group,68 cases)or no special treatment(the untreated group,170 cases)ac-cording to their condition.HPV typing was performed on cervical exfoliated cells of the patients with regular follow-up,and the HPV negative conversion was statistically analyzed.Results Single infection was the main infection in the 278 cases of female HPV infection[65.8%(183/278)].The top three high-risk HPV infection were HPV52[23.7%(66/278)],HPV16[19.8%(55/278)]and HPV58[14.4%(40/278)]respectively,and HPV81 was the main low-risk type,with an infection rate of 11.9%(33/278).The first-year follow-up HPV negative conversion rates of the patients in the operation group,the medication group and the untreated group were 62.5%(25/40),61.8%(42/68)and 30.0%(51/170),respectively.There was no significant difference in the first-year follow-up HPV negative conversion rates of the patients in the operation group and the medica-tion group(P>0.05).There were statistically significant differences in the first-year follow-up HPV negative conversion rates of the patients in the medication group and the untreated group(P<0.05).In the untreated group,the HPV negative conversion rate in the second year of follow-up[45.9%(50/109)]was significantly higher than that in the first year[30.0%(51/170)],and the HPV negative conversion rate in the first and second years of follow-up for the patients≤45 years old[39.4%(41/104)and 53.6%(37/69),respectively]was significantly higher than that of those older than>45 years old[15.2%(10/66)and 32.5%(13/40),re-spectively],and the difference was statistically significant(P<0.05).Conclusion Surgery or drug therapy can significantly improve the negative conversion rate of HPV,the clinician can choose the appropriate treat-ment according to the patient's condition.
Human papillomavirusGenotypingNegative conversion rate
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