微小RNA-324-5p在恶性肿瘤中的作用及其机制研究进展
Research progress on the role and mechanism of microRNA-324-5p in malignant tumors
杨清诚 1刘晓华1
作者信息
- 1. 天津体育学院运动健康学院/天津市运动生理学与运动医学重点实验室,天津 301617
- 折叠
摘要
微小RNA(miRNA)是一类长度约19～25个核苷酸的非编码单链RNA,可与靶基因3'非翻译区完全或不完全结合,抑制信使RNA翻译或促进其降解,发挥转录后调控作用.目前,已在多种恶性肿瘤中发现miR-324-5p的表达存在异常,并且在不同肿瘤中miR-324-5p通过作用于不同的靶基因调控着癌细胞的增殖、侵袭、转移和凋亡,表现出抑癌或促癌作用.该文对miR-324-5p在恶性肿瘤中的重要生物学功能和相关机制进行了综述,旨在为恶性肿瘤相关标志物和有效治疗靶点的开发提供新思路.
Abstract
MicroRNAs(miRNA)is a class of non-coding single-stranded RNAs with length of about 19-25 nucleotides,which can completely or incompletely bind to the 3'ntranslated region(3'UTR)of the tar-get gene,inhibit the translation of messenger RNAs or promote its degradation,and exert post-transcriptional regulatory effects.At present,it has been found that the expression of miR-324-5p is abnormal in a variety of malignant tumors,and miR-324-5p regulates the proliferation,invasion,metastasis and apoptosis of cancer cells by acting on different target genes in different tumors,showing either oncogenic or pro-oncogenic effects.This article reviews the important biological functions and related mechanisms of miR-324-5p in malignant tumors,aiming to provide new ideas for the development of malignant tumor-related markers and effective therapeutic targets.
关键词
微小RNA-324-5p/恶性肿瘤/机制/生物标志物/综述Key words
MicroRNA-324-5p/Malignant tumor/Mechanism/Biomarkers/Review引用本文复制引用
基金项目
"十三五"国家重点研发计划项目(2017YFC0211603)
出版年
2024
国家科技期刊平台
NSTL
万方数据