Research progress on the role and mechanism of microRNA-324-5p in malignant tumors
MicroRNAs(miRNA)is a class of non-coding single-stranded RNAs with length of about 19-25 nucleotides,which can completely or incompletely bind to the 3'ntranslated region(3'UTR)of the tar-get gene,inhibit the translation of messenger RNAs or promote its degradation,and exert post-transcriptional regulatory effects.At present,it has been found that the expression of miR-324-5p is abnormal in a variety of malignant tumors,and miR-324-5p regulates the proliferation,invasion,metastasis and apoptosis of cancer cells by acting on different target genes in different tumors,showing either oncogenic or pro-oncogenic effects.This article reviews the important biological functions and related mechanisms of miR-324-5p in malignant tumors,aiming to provide new ideas for the development of malignant tumor-related markers and effective therapeutic targets.
国家科技期刊平台
NSTL
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