首页|炎症性肠病患者应用抗TNF-α单抗发生结核风险的研究进展

炎症性肠病患者应用抗TNF-α单抗发生结核风险的研究进展

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
炎症性肠病(IBD)是一种胃肠道慢性非特异性复发性炎症性疾病。抗肿瘤坏死因子-α(TNF-α)单抗的出现极大地改善了IBD患者的预后，但同时也增加了患者发生活动性结核的风险。中国是结核高负担国家，临床医生应高度重视抗TNF-α单抗导致结核的风险。该文回顾了潜伏性结核感染及再激活的机制、抗TNF-α单抗导致结核的风险，以及国内外指南的诊疗推荐，期望能为合并潜伏性结核感染的IBD患者在应用抗TNF-α单抗时提供一些参考依据。
Research progress on the risk of tuberculosis in patients with inflammatory bowel disease treated with anti-TNF-α monoclonal antibody
Inflammatory bowel disease(IBD)is a chronic non-specific recurrent inflammatory disease of the gastrointestinal tract.The emergence of anti-tumor necrosis factor-α(TNF-α)monoclonal antibody has greatly improved the prognosis of IBD patients,but also increased the risk of active tuberculosis.China is a country with high burden of tuberculosis and clinicians should attach great importance to the risk of tubercu-losis caused by anti-TNF-α monoclonal antibody.This paper reviews the mechanism of latent tuberculosis in-fection and reactivation,the risk of tuberculosis caused by anti-TNF-α monoclonal antibody,and the diagnosis and treatment recommendations of domestic and foreign guidelines.It is expected to provide some references for IBD patients with latent tuberculosis infection when using anti-TNF-α monoclonal antibody.

Inflammatory bowel diseaseAnti-TNF-α monoclonal antibodyTuberculosis infec-tionLatent tuberculosis screeningReview

苏建淋、廖盛涛、李传飞、吕琳

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重庆医科大学附属第二医院消化内科,重庆 400010

炎症性肠病 抗TNF-α单抗 结核感染 潜伏性结核筛查 综述

重庆市科卫联合医学科研项目重庆市中青年医学高端人才基金项目重庆医科大学附属第二医院宽仁英才(骨干人才)基金项目

2020GDRC01411-02013-003-023

2024

10.3969/j.issn.1009-5519.2024.16.028

现代医药卫生
重庆市卫生信息中心

现代医药卫生

影响因子：0.758
ISSN：1009-5519
年,卷(期)：2024.40(16)