炎症性肠病患者应用抗TNF-α单抗发生结核风险的研究进展
Research progress on the risk of tuberculosis in patients with inflammatory bowel disease treated with anti-TNF-α monoclonal antibody
苏建淋 1廖盛涛 1李传飞 1吕琳1
作者信息
- 1. 重庆医科大学附属第二医院消化内科,重庆 400010
- 折叠
摘要
炎症性肠病(IBD)是一种胃肠道慢性非特异性复发性炎症性疾病.抗肿瘤坏死因子-α(TNF-α)单抗的出现极大地改善了IBD患者的预后,但同时也增加了患者发生活动性结核的风险.中国是结核高负担国家,临床医生应高度重视抗TNF-α单抗导致结核的风险.该文回顾了潜伏性结核感染及再激活的机制、抗TNF-α单抗导致结核的风险,以及国内外指南的诊疗推荐,期望能为合并潜伏性结核感染的IBD患者在应用抗TNF-α单抗时提供一些参考依据.
Abstract
Inflammatory bowel disease(IBD)is a chronic non-specific recurrent inflammatory disease of the gastrointestinal tract.The emergence of anti-tumor necrosis factor-α(TNF-α)monoclonal antibody has greatly improved the prognosis of IBD patients,but also increased the risk of active tuberculosis.China is a country with high burden of tuberculosis and clinicians should attach great importance to the risk of tubercu-losis caused by anti-TNF-α monoclonal antibody.This paper reviews the mechanism of latent tuberculosis in-fection and reactivation,the risk of tuberculosis caused by anti-TNF-α monoclonal antibody,and the diagnosis and treatment recommendations of domestic and foreign guidelines.It is expected to provide some references for IBD patients with latent tuberculosis infection when using anti-TNF-α monoclonal antibody.
关键词
炎症性肠病/抗TNF-α单抗/结核感染/潜伏性结核筛查/综述Key words
Inflammatory bowel disease/Anti-TNF-α monoclonal antibody/Tuberculosis infec-tion/Latent tuberculosis screening/Review引用本文复制引用
基金项目
重庆市科卫联合医学科研项目(2020GDRC014)
重庆市中青年医学高端人才基金项目(11-020)
重庆医科大学附属第二医院宽仁英才(骨干人才)基金项目(13-003-023)
出版年
2024
国家科技期刊平台
NSTL
万方数据